Transformation is a process in which bacteria take up new DNA released by dead cells and integrate it into their own genomes. In Streptococcus pneumoniae (which causes many cases of pneumonia, inner-ear infections, and meningitis), the ability to carry out transformation requires from 105 to 124 genes, collectively termed the com regulon. The com regulon is activated in response to a protein called competence-stimulating peptide (CSP), which is produced by the bacteria and exported into the surrounding medium. When enough CSP accumulates, it attaches to a receptor on the bacterial cell membrane, which then activates a regulator protein that stimulates the transcription of genes within the com regulon and sets in motion a series of reactions that ultimately result in transformation. Does the com regulon in Streptococcus pneumoniae exhibit positive or negative control? Explain your answer

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Transformation is a process in which bacteria take up new DNA
released by dead cells and integrate it into their own genomes. In Streptococcus pneumoniae (which causes many
cases of pneumonia, inner-ear infections, and meningitis), the ability to
carry out transformation requires from 105 to 124 genes, collectively
termed the com regulon. The com regulon is activated in response to a
protein called competence-stimulating peptide (CSP), which is produced
by the bacteria and exported into the surrounding medium. When
enough CSP accumulates, it attaches to a receptor on the bacterial cell
membrane, which then activates a regulator protein that stimulates the
transcription of genes within the com regulon and sets in motion a series
of reactions that ultimately result in transformation. Does the com
regulon in Streptococcus pneumoniae exhibit positive or negative
control? Explain your answer

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