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- What additional biological questions can be answered if one has the complete sequence of an organisms genome as compared with the sequences of individual genes?Which of the following is NOT an activity carried out in the field of bioinformatics? a. collecting and storing DNA sequence information produced by various genome sequencing projects b. analyzing genome sequences to determine the location of genes c. determining the three-dimensional structure of proteins d. comparing genomes of different species e. none of theseWhich goals of the Human Genome Project do you think are themost important? Why? Discuss the types of ethical problems thatmight arise as a result of identifying all of our genes.
- Hi, I would like to know which program is used for the graphical presentation of the results of a meta-analysis of genome-wide linkage scans?Bioinformatics is the science of using computational methods (specialized software) to decipher the biological meaning of information contained within organismal system. Comparisons of experimental data involving DNA sequences generated by different laboratories are critically dependent on the use of a universally agreed-upon standard of analysis. Which of the following is universally used as the agreed-upon standard of analysis for these comparisons? Group of answer choices A GenBank database. A species reference sequence (RefSeq) system. A genomic library collection. A ChIP/chip analysis system.What are some possible research questions and practical applications that could be addressed by creating organisms with artificial chromosomes and synthetic genomes? What might be some potential safety, environmental, social, and ethical concerns about creating organisms with synthetic genomes?
- "DNA Sequence Analysis Relies on Bioinformatics Applications and Genome Databases". Explain this ?Describe the goals, processes, and outcomes of the Human Genome Project. Who were the major "players" involved? What were the successes and challenges?"Whole-Genome Sequencing Is Widely Used for Sequencing and Assembling Entire Genomes". Explain this ?
- With the many high throughput experiments that are used in biomedical research, how are some ways to integrate those datasets using systems biology? For example, if you had a microarray dataset that annotated gene expression levels and a proteomics dataset that identifed protein interactions, how could you jointly use both datasets to identify markers for a disease? Explain each step.Your advisor, a brilliant bioinformatician, has high regard for your intellect and industry. she suggests that you write a computer program that will identify the exons of protein- coding genes directly from the sequence of the human genome. In preparation for that task, you decide to write down a list of the features that might distinguish protein- coding sequences from intronic DNA and from other sequences in the genome. What features would you list?Increasingly, whole-genome sequencing of individuals is being done to help identify and treat medical conditions. Genome sequencing invariably identifies a number of variations, some common and some rare, that might be clinically relevant. For example, suppose a person had their genome sequenced to help determine their risk for cardiovascular disease and, just by chance, the sequence revealed that they carry one or more variants that predispose them to cancer or Alzheimer disease. Does the sequencing laboratory or physician have an obligation to report this finding, which was not the purpose of the sequencing and which the patient did not request? What about reporting variants for which no or limited information can be provided about their clinical significance? Does the answer to this question differ for sequencing done on children?
