1. What is the chemical reaction rate constant responsible for the degradation of drug X in this solution? a. 0.099 month b. 0.197 month' c. 0.693 month d. 7.03 month

Fundamentals Of Analytical Chemistry
9th Edition
ISBN:9781285640686
Author:Skoog
Publisher:Skoog
Chapter30: Kinetic Methods Of Analysis
Section: Chapter Questions
Problem 30.12QAP
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The chemical stability of drug X was evaluated for possible inclusion in a novel subcutancous implant. For this
purpose, an aqueous solution of 120 ng/mL of the drug was prepared and placed in an incubator set at 37°C, the
body's normal temperature, and the following data for amount remaining vs. time was generated. Based on this data,
answer the following two questions.
1. What is the chemical reaction rate constant
responsible for the degradation of drug X in
this solution?
Time (months)
[Drug] (ng/mL)
5
73.2
7
60.1
a. 0.099 month
b. 0.197 month'
c. 0.693 month
d. 7.03 month
10
46.4
12
37.2
14
30.3
16
25.5
19
18.6
23
12.6
2. What would be an appropriate shelf-life that you would assign for this drug under these conditions?
а. 1 day
b. 7 days
c. 23 days
d. 32 days
Transcribed Image Text:The chemical stability of drug X was evaluated for possible inclusion in a novel subcutancous implant. For this purpose, an aqueous solution of 120 ng/mL of the drug was prepared and placed in an incubator set at 37°C, the body's normal temperature, and the following data for amount remaining vs. time was generated. Based on this data, answer the following two questions. 1. What is the chemical reaction rate constant responsible for the degradation of drug X in this solution? Time (months) [Drug] (ng/mL) 5 73.2 7 60.1 a. 0.099 month b. 0.197 month' c. 0.693 month d. 7.03 month 10 46.4 12 37.2 14 30.3 16 25.5 19 18.6 23 12.6 2. What would be an appropriate shelf-life that you would assign for this drug under these conditions? а. 1 day b. 7 days c. 23 days d. 32 days
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