11.The critical decision point at which a cell determines its fate at the end of the G1 phase of the cell cycle is called ----. a. transition point. b. resolution point. c. commitment point. d. restriction point. 12. In the familial form of retinoblastoma, multiple foci of tumors are seen arising in both eyes, which is not seen in sporadic form of the disease. This is because ----. a. familial form of the disease progresses rapidly b. mitogenic factors trigger growth in the familial form c. all retinal cells in the familial disease carry one defective copy of the Rb gene at birth d. sporadic form has other active tumor suppressors 13. What ensures that the cell cycle moves in only one direction, e.g. from G1 → S, and not go backwards? a. the cyclin from one phase is degraded as the cell moves to the next phase b. level of the appropriate cyclin of next phase rises as the cell is about to enter that phase c. a and b d. level of appropriate CDK rises and falls at each phase e. a, b and c

Biochemistry
6th Edition
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Reginald H. Garrett, Charles M. Grisham
Chapter28: Dna Metabolism: Replication, Recombination, And Repair
Section: Chapter Questions
Problem 19P: Figure 28.11 depicts the eukaryotic cell cycle. Many cell types “exit� the cell cycle and...
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11.The critical decision point at which a cell determines its fate at the end of the G1 phase of the cell cycle is
called ----.
a. transition point.
b. resolution point.
c. commitment point.
d. restriction point.
12. In the familial form of retinoblastoma, multiple foci of tumors are seen arising in both eyes, which is not
seen in sporadic form of the disease. This is because --
a. familial form of the disease progresses rapidly
b. mitogenic factors trigger growth in the familial form
c. all retinal cells in the familial disease carry one defective copy of the Rb gene at birth
d. sporadic form has other active tumor suppressors
13. What ensures that the cell cycle moves in only one direction, e.g. from G1 → S, and not go backwards?
a. the cyclin from one phase is degraded as the cell moves to the next phase
b. level of the appropriate cyclin of next phase rises as the cell is about to enter that phase
c. a and b
d. level of appropriate CDK rises and falls at each phase
e. a, b and c
Transcribed Image Text:11.The critical decision point at which a cell determines its fate at the end of the G1 phase of the cell cycle is called ----. a. transition point. b. resolution point. c. commitment point. d. restriction point. 12. In the familial form of retinoblastoma, multiple foci of tumors are seen arising in both eyes, which is not seen in sporadic form of the disease. This is because -- a. familial form of the disease progresses rapidly b. mitogenic factors trigger growth in the familial form c. all retinal cells in the familial disease carry one defective copy of the Rb gene at birth d. sporadic form has other active tumor suppressors 13. What ensures that the cell cycle moves in only one direction, e.g. from G1 → S, and not go backwards? a. the cyclin from one phase is degraded as the cell moves to the next phase b. level of the appropriate cyclin of next phase rises as the cell is about to enter that phase c. a and b d. level of appropriate CDK rises and falls at each phase e. a, b and c
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