18. You created a transgenic mouse in which all B cells express heavy and light chain of immunoglobulins specific to chicken ovalbumin (OVA). The mouse also expresses the gene for OVA in peripheral tissues (skin, liver, spleen, and gut). The phenotype of this mouse will be A. no naïve B cells B. no naïve T cells C. naïve T cells with reduced expression of OVA-specific TCRs on cell surface D. naïve B cells with reduced expression of OVA-specific BCRs on cell surface E. naïve B cells with increased expression of OVA-specific BCRs on cell surface

18. You created a transgenic mouse in which all B cells express heavy and light chain of immunoglobulins specific to chicken ovalbumin (OVA). The mouse also expresses the gene for OVA in peripheral tissues (skin, liver, spleen, and gut). The phenotype of this mouse will be A. no naïve B cells B. no naïve T cells C. naïve T cells with reduced expression of OVA-specific TCRs on cell surface D. naïve B cells with reduced expression of OVA-specific BCRs on cell surface E. naïve B cells with increased expression of OVA-specific BCRs on cell surface

Biology: The Dynamic Science (MindTap Course List)

4th Edition

ISBN:9781305389892

Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan

Chapter45: Defenses Against Disease

Section: Chapter Questions

Problem 5TYK

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1:Describe the various stages of T cells and the events that occur during each of these stages during T cell development. What stages of T cell development would be affected in mice with the following genetic mutations? Justify your answer. a) Mice that do not express MHC Class I molecule. b) Mice that do not express Rag1 c) Mice that do not express the pre-T-alpha chain 2:Transgenic mice that have constitutive expression of Rag1/2 are being used in an experiment to study pre-BCR signaling. Based on your knowledge of early B cell development, speculate on what might be the fate of BCR rearrangement and how will this affect further development of B cells in the bone marrow? please answer in full detail I want long well explained answers.
9. Transgenic mice are generated that are incapable of expressing the poly-immunoglobulin receptor. Secretion of which of the following antibody will be altered in this mice (A) IgA (B) IgD (C) IgE (D) IgG
1. Transgenic mice are generated that are capable of expressing the poly-immunoglobulin receptor. Secretion of whic of the following antibody isotypes will be altered in these mice (a) IgA (b) IgD (c) IgE (d) IgG
1. The fact that the immune system has such great flexibility that it is able to produce such a large pool of antibody proteins in which at lease on in that pool would be able to recognize any unique antigen to which you might be exposed is because Select one: a. the light and heavy chain amino acid sequences vary widely within an antibody class b. antibody proteins contain multiple antigen binding sites c. the hyper-variable heavy chain sequence leads to wide antigen recognition d. the amino acid sequences of the antigen binding site varies tremendously between different antibody molecules e. an antibody protein can bind many different types of antigens Clear my choice 2. Activation of any of the Complement Cascades in response to a bacterial infection occurs rapidly because Select one: A. activation of all the pathways leads to a fast response B. bacteria are easily and quickly recognized by the initiating Complement pathway enzymes. C. the first protein in the system (Cl) is the…
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1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and iv
1. Antigens are made up of specific sequences of amino acids called ----- that determine their structure. A. epitopes B. multivalent sites C. paratropes D. constant regions 2. Which scenario best describes antibody cross-reactivity? A. A single pathogen with multiple epitopes is recognized by a multivalent antibody. B. Multipleepitopes are recognized by multiple antibodies C. A single epitope is recognized by multiple antibodies D. Two distinct, but structurally similar epitopes are recognized by the same antibody 3. What is the major benefit of cross-reactivity? A. Cross-reactivity permits the allergic response. B. Cross-reactivity promotes a faster immune response against unrelated pathogens. C. Cross-reactivity enhances immunity by providing protection against related pathogens. D. Cross-reactivity allows the immune system to respond to pathogens in various locations within the host (i.e., skin, mucosal tissues, extracellular fluids, etc.)
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