1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase, Write an expression for the reaction velocity.
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1G. Please help me in detail. For Molecular Mechanism of ATP versus GTP selectivity of adenylate kinase,
Write an expression for the reaction velocity.
Step by step
Solved in 3 steps
- 1H. please help me in detail. For molecular Mechanism of ATP versus GTP selectivity of adenylate kinase4. a. Calculate the KM (Michaelis constant) and the vmax (the maximum initial rate) for both substrates (sphingosine and ATP). Show your work, and be careful about units. b. threo-dihydrosphingosine, a stereoisomer of sphingosine, is an inhibitor of sphingosine kinase. What kind of inhibitor (competitive, uncompetitive, noncompetitive) is threo-dihydrosphingosine? Citing information from the Lineweaver-Burke plots, explain how you can tell.Hi, help please. Discuss each method of regulating phosphofructokinase below as indicated by the circle. Discuss 1.) The type of regulation occurring, 2.) What compound or condition performs the regulation, 3.) How/why it influences the enzyme activity.
- Tags: Biology, chemistry, biochemistry, metabolic pathway, cellular respiration, ATP synthase, alzheimer's disease It was observed that the β-subunit of the ATP synthase has a low level of expression in Alzheimer’s disease (neurodegenerative disorder). Explain a possible link between this observation and the said disease.Please refer to the model, the answer may be brief.. thank you so much for answering both... i appreciate it1. Explain the mechanism of action of the adenyl cyclic system using a schematic diagram. 2. Cite a metabolic pathway where active protein kinase is needed and explain its mechanism of actionb) Following this experiment, you would like to elucidate the mechanism of action of pyruvate kinase. Unfortunately, the crystal structure of pyruvate kinase is not available, which requires the enzyme to be modelled based on the available three-dimensional structures of related enzymes. Suggest a bioinformatics approach that can be conducted to perform this study.
- MULTIPLE CHOICE In patients with Lesch Nyhan Syndrome, purine nucleotides are overproduced and over excreted. The hypoxanthine analogue Allopurinol, which effectively treats gout , has no effect on the severe neurological symptoms of Lesch- Nyhan patients because it does not A. decrease de novo pyrimidine synthesis B. decrease de novo purine synthesis C. decrease urate synthesis D. increase PRPP levels (Phosphoribosyl pyrophosphate)1B. please help me in detail. Draw a graph of free energy G (y-axis) vs reaction progress (x-axis) that illustrates what the kinase is doing in terms of the free energy by showing (i) the substrate (also label what the substrate is [it’s name]), (ii) the products (also give the name of the products), (iii) draw and label the uncatalyzed and catalyzed reactions, and be sure that the parts of the graph are properly labeled..Choices for each phrases: a, b, y, t, v, e; gtp, cgt, atp, adp, camp, catp; gtp, gdp, atp, adp, camp, catp; histamine kinase, gaunylyl cyclamen, phosphorylation, adenylyl cyclase
- 1E In terms of binding adenylate kinase, the Kd for ATP is ~50 M and the KI for GMP-PCP is ~50 nM. Explain how this may be possible in terms of molecular interactions. Name 4 different types of molecular interactions that may contribute to the increased binding affinity exhibited by GMP-PCP. Please help me in details1C One of the major findings of this study is that GTP arrests the enzyme. Draw (i) the natural substrate ATP; (ii) the substrate analog, GTP, and (iii) the GMP-PCP molecule. Indicate where they are different. For each molecule, indicate where the hydrolysable (scissile bond) is located. Please help meFollowing this experiment, you would like to elucidate the mechanism of action of pyruvatekinase. Unfortunately, the crystal structure of pyruvate kinase is not available, whichrequires the enzyme to be modelled based on the available three-dimensional structures ofrelated enzymes. Suggest a bioinformatics approach that can be conducted to perform thisstudy.
