2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine. a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has times higher [H*] than the small intestine. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Stomach (pH = 2.0): Overall Charge: Small Intestine (pH= 6.0): Overall Charge: c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin is more likely to be absorbed into the bloodstream via the stomach than the small intestine.

2. Aspirin can be absorbed into the blood through the cells lining the stomach and the small intestine. a. The pH inside the stomach is ~ 2.0 and the pH inside the small intestine is ~ 6.0. The stomach has times higher [H*] than the small intestine. b. The pKa of aspirin is 3.5. Draw the predominant form of aspirin and its overall charge (-1,0 or +1) when it is in the stomach or in the small intestine: Stomach (pH = 2.0): Overall Charge: Small Intestine (pH= 6.0): Overall Charge: c. Drug absorption requires passage through the hydrophobic plasma membrane, the rate of which is determined by the polarity of the drug molecule: charged and extremely polar molecules pass slowly, whereas neutral and hydrophobic ones pass rapidly. Based on your answer in #2b, explain why aspirin is more likely to be absorbed into the bloodstream via the stomach than the small intestine.

Anatomy & Physiology

1st Edition

ISBN:9781938168130

Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble

Chapter2: The Chemical Level Of Organization

Section: Chapter Questions

Problem 24RQ: Ty is three years old and as a result of a stomach bug has been vomiting for about 24 hours. His...

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