2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner. 2.1. What is Paul's reason for saying that John's diet is not good? 2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners?

Ebk:Nutrition & Diet Therapy
10th Edition
ISBN:9780357391747
Author:DEBRUYNE
Publisher:DEBRUYNE
Chapter10: Fitness And Nutrition
Section: Chapter Questions
Problem 2SC
icon
Related questions
Question
2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started
on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner.
2.1. What is Paul's reason for saying that John's diet is not good?
2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners?
2.3. Joseph, John and Paul decided to join a triathlon. Mary joined them to cheer for John. Unfortunately, a sudden storm sank their boat while they were on their way to the triathlon
site. All managed to survive by swimming to a tiny, uninhabited island. They lost all their things, including Mary's insulin.
It took three days, with no food or shelter before they were rescued. By then, Mary was already very weak. Based on your knowledge of metabolism, determine the current state of
Mary's metabolic pathways (whether active or inactive) in her various organs.
Organ
Pathway
State
Liver
Glycolysis
Gluconeogenesis
Glycogen synthesis
Fatty acid synthesis
Beta-oxidation of FA
Muscle
Glycolysis
Citric Acid cycle
Fatty acid synthesis
Adipose
Glycogen synthesis
Fatty acid synthesis
2.4. What would be the expected intracellular levels of the following metabolites in Mary's liver? Indicate whether high, low or normal.
Metabolite
Level
Glucose
Ketone bodies
Free fatty acids
NADH
Acetyl-CoA
Oxaloacetate
2.5. Overexposure to sunlight has caused a mutation in Joseph's gene coding for glucose-6-phosphatase. Soon after, he became delirious.
2.5.1. What pathway will become inactive because of the mutation?
2.5.2. Explain the consequence of inactivating this pathway and its effects on Joseph.
Transcribed Image Text:2. John, Paul and Joseph were close friends with a common interest in fitness. John, who had recently started preparing for his first marathon mentioned to his friends that he had started on a low-carbohydrate, protein-rich diet so that he can be muscular but lean. However, Paul said this is actually not a good diet for a marathoner. 2.1. What is Paul's reason for saying that John's diet is not good? 2.2. John's girlfriend Mary also wanted to join the marathon, but was advised by her doctor not to, as she was diabetic. Why would diabetes be a problem for runners? 2.3. Joseph, John and Paul decided to join a triathlon. Mary joined them to cheer for John. Unfortunately, a sudden storm sank their boat while they were on their way to the triathlon site. All managed to survive by swimming to a tiny, uninhabited island. They lost all their things, including Mary's insulin. It took three days, with no food or shelter before they were rescued. By then, Mary was already very weak. Based on your knowledge of metabolism, determine the current state of Mary's metabolic pathways (whether active or inactive) in her various organs. Organ Pathway State Liver Glycolysis Gluconeogenesis Glycogen synthesis Fatty acid synthesis Beta-oxidation of FA Muscle Glycolysis Citric Acid cycle Fatty acid synthesis Adipose Glycogen synthesis Fatty acid synthesis 2.4. What would be the expected intracellular levels of the following metabolites in Mary's liver? Indicate whether high, low or normal. Metabolite Level Glucose Ketone bodies Free fatty acids NADH Acetyl-CoA Oxaloacetate 2.5. Overexposure to sunlight has caused a mutation in Joseph's gene coding for glucose-6-phosphatase. Soon after, he became delirious. 2.5.1. What pathway will become inactive because of the mutation? 2.5.2. Explain the consequence of inactivating this pathway and its effects on Joseph.
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Knowledge Booster
Physical activity
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Ebk:Nutrition & Diet Therapy
Ebk:Nutrition & Diet Therapy
Health & Nutrition
ISBN:
9780357391747
Author:
DEBRUYNE
Publisher:
Cengage
Nutrition: Concepts and Controversies -  Standalo…
Nutrition: Concepts and Controversies - Standalo…
Health & Nutrition
ISBN:
9781305627994
Author:
Frances Sizer, Ellie Whitney
Publisher:
Brooks Cole
Essentials of Pharmacology for Health Professions
Essentials of Pharmacology for Health Professions
Nursing
ISBN:
9781305441620
Author:
WOODROW
Publisher:
Cengage
Anatomy & Physiology
Anatomy & Physiology
Biology
ISBN:
9781938168130
Author:
Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:
OpenStax College
Nutrition Now
Nutrition Now
Health & Nutrition
ISBN:
9781337415408
Author:
Brown
Publisher:
Cengage
Comprehensive Medical Assisting: Administrative a…
Comprehensive Medical Assisting: Administrative a…
Nursing
ISBN:
9781305964792
Author:
Wilburta Q. Lindh, Carol D. Tamparo, Barbara M. Dahl, Julie Morris, Cindy Correa
Publisher:
Cengage Learning