21p 21g 1. You performed SNP microaray genotyping on a child diagnosed with Down syndrome and his parents. Only the markers close to the centromere of chromosome 21 are shown. What can you conclude from these data? A. Father т a. Nondisjunction occurred in the father during meiosis 1 b. Nondisjunction occurred in the father during meiosis 2 c. Nondisjunction occurred in the mother during meiosis 1 d. Nondisjunction occurred in the mother during meiosis 2 e. The child does not have trisomy 21. A. Mother Child 2. What does the Philadelphia chromosome refer to?
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- Part A Diagram A represents a chromosomal inversion event. A, B, C, D, E, F, are chromosomal loci. Represents a centromere. Diagram B shows a crossing over event between non-sister chromatids (darker vs. lighter lines) during meiosis I. A A Which of the following represents a recombinant chromosome resulting from the cross-over event shown in diagram B? E F MARK ALL THE ANSWES THAT APPLY. Inversion A E C B B EEEE(X^X^) and one male (X"). 12. The following are the gene order on the chromosomes of an individual who is heterozygous for this translocation. translocations (a.unbalanced breciprocal C. Robertsonian MN OP QR N067 89 34 5P QR 3 4 5 6 7 8 9 a. 0 LMNOP QR LMN067 89 345P QR 3456789 hmm Draw the synapsis (Prophase/Metaphase I) configuration dark spots b. What type of translocation is depicted by these chromosomes and what are the consequences of this chromosome rearrangement to the individual? this type of translocation is unbalanced and the major consequence here is that the chromosome number is not reciprocated leading to all sorts of problems with non-disjunction.An individual heterozygous for a reciprocal translocation possesses the following chromosomes: A B • C D E F G A B • C D V W X R S • T U E F G R S • T U V W X a. Draw the pairing arrangement of these chromosomes in prophase I of meiosis. b. Diagram the alternate, adjacent-1, and adjacent-2 segregation patterns in anaphase I of meiosis. c. Give the products that result from alternate, adjacent-1, and adjacent-2 segregation.
- A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. Q. List all the different types of gametes that might be produced by the man.A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. Q. What types of zygotes will develop when each of gametes produced by the man fuses with a normal gamete produced by the woman?Inversions are said to “suppress crossing over.” Is this terminologytechnically correct? If not, restate the descriptionaccurately.
- A woman with normal chromosomes mates with a man who also has normal chromosomes. a. Suppose that, in the course of oogenesis, the woman’s sex chromosomes undergo nondisjunction in meiosis I; the man’s chromosomes separate normally. Give all possible combinations of sex chromosomes that this couple’s children might inherit and the number of Barr bodies that you would expect to see in each of the cells of each child. b. What chromosome combinations and numbers of Barr bodies would you expect to see if the chromosomes separate normally in oogenesis, but nondisjunction of the sex chromosomes takes place in meiosis I of spermatogenesis?ISlate edu/ d2l/le/content/5003190/viewContent/44248878/View Google Tranx 4 My Drive-G X 4. Suppose that a parent Drosophila is e ca* ca The gamete frequency is as follows: e'ca e ca 16% e'ca е са 31% 14% 29% a. Circle the recombinant gametes. b. What is the map distance between the ebony and claret genes?A young couple is planning to have children. Knowing that there have been a substantial number of stillbirths, miscarriages, and fertility problems on the husband’s side of the family, they see a genetic counselor. A chromosome analysis reveals that, whereas the woman has a normal karyotype, the man possesses only 45 chromosomes and is a carrier of a Robertsonian translocation between chromosomes 22 and 13. a. List all the different types of gametes that might be produced by the man. b. What types of zygotes will develop when each of gametes produced by the man fuses with a normal gamete produced by the woman? c. If trisomies and monosomies entailing chromosomes 13 and 22 are lethal, approximately what proportion of the surviving offspring are expected to be carriers of the translocation?
- of der(X) der(22) 22 der(X) 22 der(X) 22 First row is mother, second row is first daughter, third row is second daughter. Phenotype in first daughter was much more severe than second daughter. Give best explanation: O Inactivation in second daughter spread to the extra chromosome 22 segment O Having 45 chromosomes always gives a more severe phenotype than 46 chromosomes Pattern of inactivation in other tissues, including brain might differ, giving functional 22q monosomy O The presence of the third X in the second daughter decreases effect of genetic abnormality O irst daughter has a Turner-like syndrome, which explains severity --------- ---------- ---------- ------------ ---------. ------------- ------------ OO ixin the experiment of following chromosomal dna mvement througgh meiosis, why. do you use non-sister chromatids to demobstrate crossing over? what combinatiobns of alleles could result from a crossover between BD and bd chromosomes? Identify two ways that meiosis contributes to genetic recombination. Why is it necessary to reduce the number of chromosomes in gametes, but not in other cell?Meiotic nondisjunction is much more likely than mitotic nondisjunction.Based on this observation, would you conclude that meioticnondisjunction is usually due to nondisjunction during meiosisI or meiosis II? Explain your reasoning?