MMIV-1IV-2III-1III-2III-3A) Using all available information, what is the correct inheritance pattern of this trait?Why?B) Draw the pattern that would result for DNA amplification of individual I-2 in theempty lane of the gel.C) What is the probability if individual IV-1 mates with an affected male that theiroffspring will be an affectedfemale?D) What is the genotype of individual II-2? Examine the pedigree of the McGraw family shown below. Certain individuals in thisfamily are affected by a brain condition that makes them more susceptible to vertigo.As a genetic counselor, you interview the family and draw DNA samples. Youdiscover that the condition is caused by a mutation that changes the sequence5'GCATTC3' to 5'GAATTC3' introducing an EcoRI cut site. You decide to amplify a1200bp fragment from the DNA that spans this mutation and then digest it withEcoRI. You run the results on a gel next to a marker that shows bands at 2000bp,1200bp, 900bp, 800bp, and 400bp. Some individuals from the pedigree areidentified on the gel.

Genetic inheritance studies reveal the way a particular gene or a genotype is inherited in the…

MM IV-1 IV-2 III-1 III-2 III-3 A) Using all available information, what is the correct inheritance pattern of this trait? Why? B) Draw the pattern that would result for DNA amplification of individual I-2 in the empty lane of the gel. C) What is the probability if individual IV-1 mates with an affected male that their offspring will be an affected female? D) What is the genotype of individual II-2?

MM IV-1 IV-2 III-1 III-2 III-3 A) Using all available information, what is the correct inheritance pattern of this trait? Why? B) Draw the pattern that would result for DNA amplification of individual I-2 in the empty lane of the gel. C) What is the probability if individual IV-1 mates with an affected male that their offspring will be an affected female? D) What is the genotype of individual II-2?

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...

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In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. What characteristics of the pedigree rule out inheritance of a trait encoded by a gene in the mtDNA as the cause of this disorder?
In a study of a muscle disorder, several affected families exhibited vision problems, muscle weakness, and deafness (M. Zeviani et al. 1990. American Journal of Human Genetics 47:904–914). Analysis of the mtDNA from affected members of these families revealed that large numbers of their mtDNA molecules possessed deletions of varying lengths. Different members of the same family and even different mitochondria from the same person possessed deletions of different sizes, so the underlying defect appeared to be a tendency for the mtDNA of affected persons to have deletions. A pedigree of one of the families studied is shown below. The researchers concluded that this disorder is inherited as an autosomal dominant trait, and they mapped the diseasecausing gene to a position on chromosome 10 in the nucleus. Q. Explain how a mutation in a nuclear gene might lead to deletions in mtDNA.
In a study of a muscle disorder, several affected families exhibitedvision problems, muscle weakness, and deafness (M. Zeviani et al. 1990.American Journal of Human Genetics 47:904–914). Analysis of themtDNA from affected members of these families revealed that largenumbers of their mtDNA molecules possessed deletions of varyinglengths. Different members of the same family and even differentmitochondria from the same person possessed deletions of differentsizes, so the underlying defect appeared to be a tendency for the mtDNAof affected persons to have deletions. A pedigree of one of the familiesstudied is shown below. The researchers concluded that this disorder isinherited as an autosomal dominant trait, and they mapped the diseasecausinggene to a position on chromosome 10 in the nucleus.a. What characteristics of the pedigree rule out inheritance of a traitencoded by a gene in the mtDNA as the cause of this disorder?b. Explain how a mutation in a nuclear gene might lead to deletions…
The figure below represents a two-generation pedigree representing the inheritance of hereditary deafness (HD), which, has been shown to be autosomal recessive. Below the pedigree (and aligned with each person in each generation) are Southern blot gels for two RFLP loci. The BamH1 RFLP locus has alleles of either 7 kb or 5 kb and the EcoRI RFLP locus gives either a 4 kb or 3 kb EcoRI fragment. a. Determine if HD is linked to either of these markers. b. If linkage is detected between HD and one of the RFLPs, are there any recombinant offspring that you can detect? c. If linkage is detected between HD and one of the RFLPs, what is the approximate map distance between the two? Do you think that this distance will efficiently and effectively allow the RFLP to track the HD gene?
What is the importance of Gregor Mendel’s Law of Inheritance in Molecular Biology?
Based on the information shown (picture) draw the pedigree for this family in the space provided below. Make sure to indicate Lee, the proband, with an arrow and use the proper svmbol for individuals who have died from cancer. Remember to also label each generation with roman numerals.
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Using the figure and the following background information answer the following questions about the figure Background: Identification of the genetic cause of hornlessness in cattle has been the subject of intensive genetic and genomic research, culminating in the nomination of two different candidate neomutations on cattle chromosome 1 that are predicted to have arisen 500-1,000 years ago: a complex allele of Friesian origin (PF), an 80,128 base pair (bp) duplication (1909352-1989480 bp), and a second, simple allele of Celtic origin (PC) corresponding to a duplication of 212 bp (chromosome 1 positions 1705834-1706045) in place of a 10-bp deletion (1706051-1706060)We report the use of genome editing using transcription activator-like effector nucleases (TALENs) to introgress the putative PC POLLED allele into the genome of bovine embryo fibroblasts to try and produce a genotype identical to what is achievable using natural mating, but without the attendant genetic drag and admixture. In…