3. The Mannich reaction can take many forms, including reactions where aromatic heterocycles are employed. Provide mechanisms for the reactions in the following sequence. Me Meo OMe MeN MeN MeN -Br MECN, 100 °C NaH, THF: Br H then 6M HCI Meo,C. Me Me MeO2C

3. The Mannich reaction can take many forms, including reactions where aromatic heterocycles are employed. Provide mechanisms for the reactions in the following sequence. Me Meo OMe MeN MeN MeN -Br MECN, 100 °C NaH, THF: Br H then 6M HCI Meo,C. Me Me MeO2C

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter16: Aldehydes And Ketones

Section: Chapter Questions

Problem 16.63P

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Please help

Meo OMe
3. The Mannich reaction can take many forms, including reactions where aromatic heterocycles are employed. Provide
mechanisms for the reactions in the following sequence.
Me
Meo
MeN
H..
OMe
MeN-
N-
MeN
Br
МеCN, 100 "C
NaH, THF;
H
Br
then 6M HCI
Meo,C
Me
Me
MeO2C

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