Please help with this assignment. Thank you 3. This figure shows different mutations discovered in the ß gene. A nucleotide substitution in thecoding region results in an amino acid sequence change from His to Tyr at the 92 position(shown in the right panel). As a result, the resulting variant Hb M binds to the heme iron andmakes it resistant to reductase. Therefore, it can no longer carry oxygen.9ĮYTranscriptionRNA splicingCap siteRNA cleavage2FrameshiftNonsense codonUnstable globinSmall deletionii i3==100 bpInitiator codon© Elsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.comIB His92Helix AHemeB Phe42EElsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.com Part Three.Suppose you are a lab technician who is responsible for diagnostic analysis of individualhemoglobinopathy cases. You have identified the mutations in each individual as outlined in the list ofcases below. You will need to develop the appropriate techniques to identify these mutations in theirfamily members, predict how these mutations affect gene expression and confirm the prediction withproper molecular techniques.For each case, please decide which thalassemia the individual has and what level of gene expressionshould be affected. Refer to the book when necessary.

There are two types of thalassemia: beta and alpha. The three types of beta thalassemia are major…

3. This figure shows different mutations discovered in the ß gene. A nucleotide substitution in the coding region results in an amino acid sequence change from His to Tyr at the 92 position (shown in the right panel). As a result, the resulting variant Hb M binds to the heme iron and makes it resistant to reductase. Therefore, it can no longer carry oxygen. Transcription RNA splicing Cap site RNA cleavage Frameshift Nonsense codon Unstable globin Small deletion ii i 100 bp [ Initiator codon Ⓒ Elsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.com H 8 His92 Helix A Heme B Phe42 Elsevier Nusshoum et al: Thompson and Thompson's Genetics i D B

3. This figure shows different mutations discovered in the ß gene. A nucleotide substitution in the coding region results in an amino acid sequence change from His to Tyr at the 92 position (shown in the right panel). As a result, the resulting variant Hb M binds to the heme iron and makes it resistant to reductase. Therefore, it can no longer carry oxygen. Transcription RNA splicing Cap site RNA cleavage Frameshift Nonsense codon Unstable globin Small deletion ii i 100 bp [ Initiator codon Ⓒ Elsevier. Nussbaum et al: Thompson and Thompson's Genetics in Medicine 7e - www.studentconsult.com H 8 His92 Helix A Heme B Phe42 Elsevier Nusshoum et al: Thompson and Thompson's Genetics i D B

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter11: Genome Alterations: Mutation And Epigenetics

Section: Chapter Questions

Problem 6QP: Although it is well known that X-rays cause mutations, they are routinely used to diagnose medical...

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