Q: Can you please help me by drawing a serie of schematic figures that demonstrates the information in…
A: Proteins undergo post-translational modifications to increase their functional diversity. The…
Q: How can a defect in p53 gene contribute to cancer development?
A: Cancer is an abnormal growth of cells which tend to proliferate in an uncontrolled way and, in some…
Q: What is the link between epigenetics and cancer?
A: Epigenetics is considered as the study in which the gene shows its behavior according to the…
Q: Define tumor-suppressor genes. Why is a mutated single copy of a tumor-suppressor gene expected to…
A: The repeated and uncontrollable division of cells forms a large mass called the tumor. Tumors might…
Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…
Q: Name four downstream effects of p53 activation.
A: Gene expression is usually accomplished through mRNA transcription and protein synthesis. p53 is a…
Q: Explain how p53 functions as a tumor suppressor gene. How can mutations in p53 lead to cancer, and…
A: Normal cell has low level of p53 protein. When DNA damage or other stress signals may trigger p53…
Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
A: Medical technology has advanced significantly over the course of many centuries. According to…
Q: Why are people more likely to develop cancer as they age? Why does inheriting a mutation increase…
A: Cancer is the name given to a collection of related diseases.In all types of cancer,some of the…
Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…
A: Genetic transformation happens when the genetic composition of an organism is transformed by the…
Q: Which genetic cancer predisposition syndrome is caused by germ-line mutations in the p53 gene and is…
A: P53 is the tumor suppressor protein (TP53 in humans) which is also described as the guardian of the…
Q: what category of cancer-related genes is it possible to find inherited variants that are associated…
A: Answer is option 3.
Q: Explain the role of epigenetic alterations in cancer ?
A: Genes are the hereditary unit in an organism and are passed on from the parental generation to the…
Q: Define tumor-suppressor genes. Why is a mutation in a single copy of a tumor-suppressor gene…
A: Tumor-supressor genes: Tumor-suppressor genes is defined as normal genes that will slow down the…
Q: Explain how enhancers work and how they are identified
A: A gene is a set of nucleotides that codes for a particular protein. Gene expression causes the…
Q: Explain the loss-of-function mutation ?
A: Mutation is a change in the sequence of genetic material naturally or by artificial factors. Such…
Q: Explain about the Cancer-causing gene formed by a mutation in a proto-oncogene ?
A: In genetics, the mutation is defined as the changes or alteration in the DNA sequences which result…
Q: Please discuss the difference between cancers caused by tumor viruses and cancers caused by…
A: Cancer is a disease where cells grow or divide uncontrolly.
Q: What DNA chemical modification can change the expression level of a target gene without sequence…
A: Introduction Epigenetics refers to the heritable or non-heritable changes in gene expression,…
Q: The effects of DNA mutations within the p53 gene on the structure and function of the protein…
A: The TP53 gene provides instructions for making a protein called tumor protein p53. This protein acts…
Q: A research study indicated that an agent in cigarette smoke caused the silencing of a tumor…
A: The TP53 gene provides instructions for making a protein called tumor protein p53 (p53). This…
Q: Some cancers are consistently associated with the deletion of a particularpart of a chromosome. Does…
A: Proto-oncogenes are normal genes that encode for proteins required for the promotion of cell cycle.…
Q: What are stem cells? Which stem cell treatment can form a benign tumor? Please explain how benign…
A: Introduction :- Stem cells are of various types : Totipotent Pleuripotent Multipotent…
Q: Mutations in proto-oncogenes that turn them into oncogenes tend to be dominant, while cancer-causing…
A: Tumor suppressor genes are the genes that suppress the formation of tumors in the cells or tissues…
Q: T7-MDM2 Myc-RYBP p53-(His-Ub), MDM2 p53 Myc-RYBP B-Actin QUESTION 12 In the RYBP case study paper,…
A: *Ring1 and YY1 binding protein (RYBP) belongs to polycomb group proteins that implicated in…
Q: How does p53 operate in normal cells?
A: The p53 gene is coded by TP 53 gene. It is named p53 because of it molecular weight53 KD.p53 gene is…
Q: Describe the underlying causes of epigenetic changes associated with cancer.
A: DNA is the genetic material in most living organisms. It is the information hub of the cell that…
Q: What are Ras protein and p53? How can mutations in the genes for these proteins contribute to…
A: TP53 is the gene that translates the protein called tumor protein p53 which acts as a tumor…
Q: majority of cancers in human are due to mutations in the p53 gene, however, cancers that are caused…
A: P 53 protein is also known as the tumor suppressor protein which is a type of phosphoprotein edit…
Q: Describe the steps by which the TP53 gene responds to DNA damage and/or cellular stress to promote…
A: It codes for a protein or a functional product rRNA (ribosomal RNA) or tRNA (transfer RNA). DNA is…
Q: Define oncogene, proto-oncogene, and tumor-suppressor gene.
A: The most common gene in people with cancer is p53 or TP53. More than 50% of cancers involve the lost…
Q: Do you think there are more unique alleles of p53 that lead to cancer or more unique alleles of Ras…
A:
Q: Which type of mutation would NOT be involved in the inactivation of a tumor suppressor gene?
A: Normal cell growth in body is controlled by - 1. Protooncogene or cellular oncogene - Protooncogene…
Q: Please distinguish driver and passenger mutations in cancer.
A: Driver mutations: Mutations in known oncogenes that help cells establish or maintain the transformed…
Q: True or False: Cancers develop when many mutations develop rather than from a single mutation
A: Cancer is a genetic disease. It’s not a single disease, rather it is two or more hundreds of…
Q: What is the difference between gain of function and loss of function mutations?
A: Mutations is a change in a DNA sequence that can be caused due to DNA replication error made during…
Q: What is the rationale for synthesizing and rapidly degrading p53 protein in the cell?
A: P53 is a nuclear transcription factor with pro apoptotic function as 50% of human Kansas carries…
Q: rationale for synthesizing and rapidly degrading p53 protein
A: p53 protein synthesised byTP53 (tumour protein 53) is a 393 amino acids long protein and is known…
Q: How does the normal p53 protein inhibit cancer development?
A: Tumor-suppressor genes code for proteins that repair damaged DNA (preventing a cell from turning…
Q: EXPLAIN BRIEFLY: Explain the molecular mechanisms of cancers caused by a P53 gene mutation.
A: Answers P53 also defined as tumour suppressor Gene. Hence it protect the cells from various damages…
Q: What were the key findings after modeling cancer through the generation of induced pluripotent stem…
A: The genetic information can be stored in the form of DNA, which may be converted into functional…
Q: List the regulatory mechanisms that might be lost in a cell producing faulty p53.
A: The cell cycle is the series of events that lead to the formation of new cells from the parent…
Q: eritable effects of gene expression that are not caused by a change in DNA sequence are called…
A: EPIGENETIC CHANGES are heritable changes in gene expression that do not involve changes to the…
Q: Explain epigenetic changes
A: Epigenetic: is the study of changes in organisms caused by modification of gene expression rather…
Q: Cellular levels of tumor suppressor protein p53 is maintained by a ubiquitin ligase protein, called…
A: From the above information, we can make the following inferences - 1. p53, as indicated in the…
Q: Suggest and explain one way epigenetics may affect the age when symptoms of Huntington's disease…
A: It is said that Several neurodegenerative diseases are caused because of the unbalanced epigenetic…
Li- Fraumeni Syndrome (LFS) is a rare hereditary cancer disease due to a mutation in the TP53 gene. Propose a treatment strategy for LFS.
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- Mutations that inactivate p53 have a recessive phenotype, whereas mutations affecting Ras are dominant. Explain the difference.Briefly describe the effects of colchicine treatment on cells. What are the genetic implications of such effects?Loss of p53 function occurs in the majority of human tumors. Name two ways in which loss of p53 function contributes to a malignant phenotype. Explain how benzo(a) pyrene can cause loss of p53 function.
- If you were to design an experiment to get p53 back into cancer cells, how would you go about that work? How would you direct p53 into the nucleus of cancer cells without directing it to the nucleus of healthy cells? As an overabundance of p53 in healthy cells would cause problems. Could someone in depth answer these questions for me and explain them cellularly.Name two ways in which loss of p53 function contributes to a malignant phenotype. Explain how benzo(a) pyrene can cause loss of p53 function. Hint: Loss of p53 function occurs in the majority of human tumors."Changes to the p53 protein structure can be caused by differences in DNA and can affect protein function." Can you give detailed explanation why this is causation and not correlation? The explanation should be related with mutation, structure changes during protein synthesis, chemical property changes in amino acids, and functions of p53 protein.
- Heritable effects of gene expression that are not caused by a change in DNA sequence are called epigenic changes. What causes these changes?What are some limitations in the use of ASOs for exon-skipping therapies in Duchenne muscular dystrophy? What is the status of current clinical trials for these exon-skipping therapies?What is the function of RAG1? What will happen if RAG1's function is lost due to mutations?
- Consider the expression “central dogma,” which refers to the flow of genetic information from DNA to RNA to protein. is the word “dogma” appropriate in this context?A research study indicated that an agent in cigarette smoke caused the silencing of a tumor suppressor gene called p53. However,upon sequencing, no mutation was found in the DNA sequence for this gene. Give two possible explanations for these results.Cancer-promoting mutations are likely to have different effects on the activity of proteins encoded byproto-oncogenes than they do on proteins encodedby tumor-suppressor genes. Explain.