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35. Dyskeratosis congenita (DKC) is a rare genetic disorder characterized by abnormal fingernails and skin pigmentation, the formation of white patches on the tongue and cheek, and progressive failure of the bone marrow. An autosomal dominant form of DKC results from mutations in the gene that encodes the RNA component of telomerase. Tom Vulliamy and his colleagues examined a series of families with autosomal dominant DKC (T. Vulliamy et al. 2004. Nature Genetics 36:447-449). They observed that the median age of onset of DKC in parents was 37 years, whereas the median age of onset in the children of affected parents was 14.5 years. Thus, DKC in these families arose at progressively younger apes in successive generations, a phenomenon known as anticipation measured the telomere lengths of members of these families; the measurements are given in the accompanying table. Telomeres normally shorten with age, so telomere length was adjusted for age; the values given in the table are the differences between the actual length and the expected length based on age. Note that the values of all members of these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the The researchers these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the telomere. Parent telomere length Child telomere length -4.7 -6.1 -6.6 -6.0 -3.9 -0.6 -1.4 -2.2 -5.2 -5.4 -2.2 -3.6 -4.4 -2.0 -4.3 -6.8 -5.0 -3.8 -5.3 -6.4 -0.6 -2.5 -1.3 -5.1 -3.9 -4.2 -5.9

35. Dyskeratosis congenita (DKC) is a rare genetic disorder characterized by abnormal fingernails and skin pigmentation, the formation of white patches on the tongue and cheek, and progressive failure of the bone marrow. An autosomal dominant form of DKC results from mutations in the gene that encodes the RNA component of telomerase. Tom Vulliamy and his colleagues examined a series of families with autosomal dominant DKC (T. Vulliamy et al. 2004. Nature Genetics 36:447-449). They observed that the median age of onset of DKC in parents was 37 years, whereas the median age of onset in the children of affected parents was 14.5 years. Thus, DKC in these families arose at progressively younger apes in successive generations, a phenomenon known as anticipation measured the telomere lengths of members of these families; the measurements are given in the accompanying table. Telomeres normally shorten with age, so telomere length was adjusted for age; the values given in the table are the differences between the actual length and the expected length based on age. Note that the values of all members of these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the The researchers these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the telomere. Parent telomere length Child telomere length -4.7 -6.1 -6.6 -6.0 -3.9 -0.6 -1.4 -2.2 -5.2 -5.4 -2.2 -3.6 -4.4 -2.0 -4.3 -6.8 -5.0 -3.8 -5.3 -6.4 -0.6 -2.5 -1.3 -5.1 -3.9 -4.2 -5.9

Biology 2e
Biology 2e
2nd Edition
ISBN:9781947172517
Author:Matthew Douglas, Jung Choi, Mary Ann Clark
Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark
Chapter14: Dna Structure And Function
Section: Chapter Questions
Problem 37CTQ: An adult with a history of tanning has his genome sequenced. The beginning of a protein-coding...
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How does the telomere length of the parents compare with the telomere length of the children? (Hint: Calculate the average telomere length of all parents and the average telomere length of all children.)

35. Dyskeratosis congenita (DKC) is a rare genetic disorder characterized by abnormal fingernails and skin pigmentation, the formation of white patches on the tongue and cheek, and progressive failure of the bone marrow. An autosomal dominant form of DKC results from mutations in the gene that encodes the RNA component of telomerase. Tom Vulliamy and his colleagues examined a series of families with autosomal dominant DKC (T. Vulliamy et al. 2004. Nature Genetics 36:447-449). They observed that the median age of onset of DKC in parents was 37 years, whereas the median age of onset in the children of affected parents was 14.5 years. Thus, DKC in these families arose at progressively younger apes in successive generations, a phenomenon known as anticipation measured the telomere lengths of members of these families; the measurements are given in the accompanying table. Telomeres normally shorten with age, so telomere length was adjusted for age; the values given in the table are the differences between the actual length and the expected length based on age. Note that the values of all members of these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the The researchers
Transcribed Image Text:35. Dyskeratosis congenita (DKC) is a rare genetic disorder characterized by abnormal fingernails and skin pigmentation, the formation of white patches on the tongue and cheek, and progressive failure of the bone marrow. An autosomal dominant form of DKC results from mutations in the gene that encodes the RNA component of telomerase. Tom Vulliamy and his colleagues examined a series of families with autosomal dominant DKC (T. Vulliamy et al. 2004. Nature Genetics 36:447-449). They observed that the median age of onset of DKC in parents was 37 years, whereas the median age of onset in the children of affected parents was 14.5 years. Thus, DKC in these families arose at progressively younger apes in successive generations, a phenomenon known as anticipation measured the telomere lengths of members of these families; the measurements are given in the accompanying table. Telomeres normally shorten with age, so telomere length was adjusted for age; the values given in the table are the differences between the actual length and the expected length based on age. Note that the values of all members of these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the The researchers
these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the telomere. Parent telomere length Child telomere length -4.7 -6.1 -6.6 -6.0 -3.9 -0.6 -1.4 -2.2 -5.2 -5.4 -2.2 -3.6 -4.4 -2.0 -4.3 -6.8 -5.0 -3.8 -5.3 -6.4 -0.6 -2.5 -1.3 -5.1 -3.9 -4.2 -5.9
Transcribed Image Text:these families are negative, indicating that their telomeres are shorter than normal for their age; the more negative the number, the shorter the telomere. Parent telomere length Child telomere length -4.7 -6.1 -6.6 -6.0 -3.9 -0.6 -1.4 -2.2 -5.2 -5.4 -2.2 -3.6 -4.4 -2.0 -4.3 -6.8 -5.0 -3.8 -5.3 -6.4 -0.6 -2.5 -1.3 -5.1 -3.9 -4.2 -5.9
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