Answered: Chromosomal DNA (human) 41% G + C…

Biology: The Unity and Diversity of Life (MindTap Course List)

15th Edition

ISBN:9781337408332

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter15: Studying And Manipulating Genomes

Section: Chapter Questions

Problem 6SQ

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Question

Huntington’s disease is a hereditary central nervous system disorder characterized by tandem repeats of the sequence 5'-CAG-3' in the gene that encodes a protein called huntingtin. The disease is progressive from generation to generation, meaning that in later generations the number of CAG repeats increases and the age of onset of symptoms decreases. Refer to Figure 21.4 and describe the sort of evidence supporting the generational increase in the number of CAG repeats.

Chromosomal DNA
(human)
41% G + C
Satellite DNA
CAG repeat
67% G + C
Shear during DNA isolation
Centrifuge to
equilibrium in CsCI
Density
A260
Bottom
Top
A FIGURE 21.4 Satellite DNA. Shearing high-molecular-weight DNA
yields short fragments that have distinctive densities and can be sepa-
rated in a CsCI gradient.

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