39. HIV could be used to cure Kaposi’s sarcoma by a. causing the cells to express exogenous surface cell markers b. activating genes for the expression of endogenous surface cell markers c. inactivating the patient’s tumor suppressing
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39. HIV could be used to cure Kaposi’s sarcoma by
a. causing the cells to express exogenous surface cell markers
b. activating genes for the expression of endogenous surface cell markers
c. inactivating the patient’s tumor suppressing genes
d. inactivating contact inhibition in the cell
e. inactivating cellular adherence
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- Overexpression of Mdr1 in cancer cells causes the cells to be a. Apoptotic b. Susceptible to chemotherapy c. Resistant to chemotherapy d. NormalThe drug pump activity of Cancer stem cells can be explained by the overexpression of: a. Mdr1 b. Muc2 c. MMR d. CYPsADAM33 metalloproteinase inhibitors are sometimes co-administered with anti-tumor monoclonal antibodies in order to _____. a. block angiogenesis b. inhibit proteasome function in tumor cells c. enhance NK-cell killing by ADCC d. promote differentiation of dendritic cells e. reduce the surface expression of MHC class I on tumor cells.
- Which of the following are mechanisms by which cancer drugs work (select all that apply)? A. Inhibit activity of oncogene B. Promote apoptosis C. Promote terminal differentiation of cells D. Inhibit drug transporters E. Promote DNA damage.Cancer cells may be more susceptible than normal cells to mitotic catastrophe in response to chemotherapeutic drugs because of which of the following (select all that apply)? A. They express unique receptors for those drugs on their surface B. They may be resistant to apoptosis C. Cancer cells have more efficient DNA repair mechanism than normal cells. D. Only cancer cells are actively dividing E. They may lack key G2/M checkpoint controlsWhich of the following statements are correct about cancer drug resistance (select all that apply)? A. It is inevitable that a tumor will eventually become resistant to a given cancer drug B. Solid tumors often develop drugs resistance through upregulating expression of drug transporters. C. If the probability of develop resistance to drug A is 1/10 and for Drug B is also 1/10, then the probility of developing resistance to Drug A and B combination therapy is 1/20. D. Effective multidrug protocols use 3 drugs that all target the same mechanisms of killing cancer cell E. Drug resistance ofter develops when p53 is inactivated
- 79. An autoimmune disease is a condition in which the White Blood Cells of the immune system attack cells that are part of the organism. This occurs because the cells if the immune system: a) fail to respond to proteins (antigens) made by the cells and fail to react. b) recognize the proteins in the cell membrane and do not react to these proteins. c) miss identify a molecule that is part of the cell as a foreign protein (antigen) and trigger an immune response (antibodies). D) none of these are correct.Which of the following factors contributes to angiogenesis as a result of a tumor growth? Select all that apply: a. Increasing tumor's access to oxygen and nutrients b. Increasing tumor's ability for growth, invasion, and metastasis c. Increasing expression of proto-oncogenes for cancer cells d. Increasing expression of tumor-suppressor genes for cancer cells________ are changes to the nucleotides in a segment of DNA that codes for a protein. a. Proto-oncogenes b. Tumor suppressor genes c. Gene mutations d. Negative regulators
- Figure 17.15 In 2011, the United States Preventative Services Task Force recommended against using the PSA test to screen healthy men for prostate cancer. Their recommendation is based on evidence that screening does not reduce the risk of death from prostate cancer. Prostate cancer often develops very slowly and does not cause problems, while the cancer treatment can have severe side effects. The PCA3 test is considered to be more accurate, but screening may still result in men who would not have been harmed by the cancer itself suffering side effects from treatment. What do you think? Should all healthy men be screened for prostate cancer using the PCA3 or PSA test? Should people in general be screened to find out if they have a genetic risk for cancer or other diseases?Most forms of cancer involvea. the activation of a single oncogene.b. the inactivation of a single tumor-suppressor gene.c. the activation of multiple oncogenes.d. the activation of multiple oncogenes and the inactivation ofmultiple tumor-suppressor genes.Sometimes, malignant cells do not stay properly anchored in tissues because of the loss of function of: a. cell walls b. oncogenes c. plasma membrane adhesion proteins d. nuclear membranes e. tumor suppressor genes
