4a BiochemistryChem 3484. Histidine, one of the 20 amino acids, contains animidazole functional group with a pKa of 6.0. Thisimidazole can either be protonated, in which case the netcharge of the molecule is +1, or deprotonated, makinghistidine neutral.a. Calculate the ratio of neutral histidine to +1 histidine at pH = 6.9.HNSladeReview Questionsc. What is the pH when +1 histidine: neutral histidine is 1:4?d. What is the pH when +1 histidine is present at 19%?b. What is the percent of neutral histidine (uncharged/deptronated) at pH = 7?HNH₂COOHe. Histidine has 2other functional groups that can be protonated/deprotonated. Ifhistidine's pka's are 2.5, 6.0, 9.0, what is the net charge of histidine at pH 9.0?

Dissociation of a weak acid is mathematically described by the Henderson-Hasselbalch equation: pH =…

4. Histidine, one of the 20 amino acids, contains an imidazole functional group with a pKa of 6.0. This imidazole can either be protonated, in which case the net charge of the molecule is +1, or deprotonated, making histidine neutral. a. Calculate the ratio of neutral histidine to +1 histidine at pH = 6.9. HN- N₁ d. What is the pH when +1 histidine is present at 19%? b. What is the percent of neutral histidine (uncharged/deptronated) at pH = 7? c. What is the pH when +1 histidine: neutral histidine is 1:4? H NH₂ COOH e. Histidine has 2other functional groups that can be protonated/deprotonated. If histidine's pka's are 2.5, 6.0, 9.0, what is the net charge of histidine at pH 9.0?

4. Histidine, one of the 20 amino acids, contains an imidazole functional group with a pKa of 6.0. This imidazole can either be protonated, in which case the net charge of the molecule is +1, or deprotonated, making histidine neutral. a. Calculate the ratio of neutral histidine to +1 histidine at pH = 6.9. HN- N₁ d. What is the pH when +1 histidine is present at 19%? b. What is the percent of neutral histidine (uncharged/deptronated) at pH = 7? c. What is the pH when +1 histidine: neutral histidine is 1:4? H NH₂ COOH e. Histidine has 2other functional groups that can be protonated/deprotonated. If histidine's pka's are 2.5, 6.0, 9.0, what is the net charge of histidine at pH 9.0?

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter3: Biological Macromolecules

Section: Chapter Questions

Problem 23CTQ: Amino acids have the generic structure seen below, where R represents different carbon-based side...

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