4. Identify: for nos. 1-5: Name of the missing metabolite in the pathway 6-10: Enzyme that catalyzed the reaction 11-15: Reaction involved 5 FAD -FADH₂ trans-2-En oyl-CoA 15 H₂O 10 3-Hyroxya.cyl-CoA NAD+ NADH + H+ beta-Ketoacyl-CoA COASH ►Acetyl-CoA Acyl-CoA (2 C Atoms Shorter) Malate Fumarate 9 Glucose Glucose-6-phosphate 11 Fructose-6-phosphate Phoshphoenolpyruvate Succinate 2 | 12 Acetyl ČOA 13 Citrate Lactate 14 Isocitrate 8 a-ketoglutarate
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- Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.CHOOSE THE CORRECT LETTER 1.What are the B-oxidation products of lauric acid (C12H2402), a major component of coconut oil?A.6 acetyl-CoA, 6 NADH, 6 FADH2B. 6 acetyl-CoA, 5 NADH, 5 FADH2C. 5 acetyl-CoA, 6 NADH, 6 FADH2D. 5 acetyl-CoA, 5 NADH, 5 FADH2 2.What is the mechanism of ATP synthesis in glycolysis?A. substrate level phosphorylationB. reductionC. oxidationD. oxidative phosphorylation 3.Which of the following enzymes need ATP as a substrate in the reaction?A.phosphoglycerate kinaseB. phosphofructokinaseC. pyruvate kinaseD.glyceraldehyde-3-phosphate dehydrogenaseComplete the table below. Consider docosanoic acid (C21H43CO2H) Questions Solutions Answers a. Label the alpha and beta carbons. b. Draw the acetyl CoA derived from this fatty acid. c. How many acetyl CoA molecules are formed by complete B-oxidation? d. How many cycles of B-oxidation are needed for complete oxidation? e. How many molecules of ATP are formed from the complete catabolism of this fatty acid?
- Complete the following paragraph describing the fate of the second 14CO-acetyl-CoA molecule incorporated into the glyoxylate cycle. The glyoxylate produced in the isocitrate reaction combines with a (A.) 2nd molecule of oxoaloacetate, B.) 2nd molecule of succinate, C.)2nd molecule of acetyl coa) in the malate synthase reaction. Malate is (A.Chiral, B.diasteromeoic C.)Achiral) ; therefore, the oxaloacetate produced from glyoxylate will be labeled at (A.Either of carboxylate carbon B. specifically at methylene carbon C. Specifically at carbonyl carbon D. Specifically at carboxylate carbon bonded to methylene).succinyl-COA synthetase will do which of the following: Select one: a. Fumarate is combined with water to become Malate b. alpha-ketoglutarate is oxidized and decarboxylated to produce Succinyl-CoA, Carbon dioxide and NADH c. Succinate is oxidized to become fumarate forming FADH2 d. Citrate is rearranged to become Isocitrate e. Malate is oxidized to become oxaloacetate forming NADH f. Pyruvate is decarboxylated to become acetyl-CoA producing NADH and Carbon dioxide g. Succinyl-CoA becomes Succinate and forms one ATP molecule and Coenzyme A-SH h. Oxaloacetate combines with the acetyl from acetyl-CoA to produce Citric acid(citrate) i. Isocitrate and then decarboxylated and oxidized to produce alpha-ketoglutarate, Carbon dioxide and NADHCHOOSE THE CORRECT LETTER 1.Which of the following substrates is used in the first oxidation step of the Kreb's cycle to produce NAH and CO2?A. isocitrateB.a-ketoglutarateC. citrateD. succinyl-CoA 2.What is the reason for isomerization of citrate to isocitrate?A.The reaction converts a tertiary alcohol, which cannot easily be oxidized, to a secondary alcohol that can be oxidizedB. Isocitrate protects cells from the toxic effects of arsenite ion.C. The reaction is one major regulatory step for the citric acid cycle because it functions as a rate limiting step.D. Isocitrate is a substrate for a reaction that occurs spontaneously without enzymatic catalysis
- Which of the following biochemical conversions can be carried out by the least number of proteins? Assume proper metabolic conditions, abundance of cofactors, necessary accessory molecules, etc. 1 propionyl-CoA → 1 succinyl-CoA 1 palmitate (16:0) → 8 acetyl-CoA 1 acetyl-CoA + 7 malonyl-CoA → 1 palmitate (16:0) 1 palmitate (16:0) → 1 acetyl-CoA + 1 myristic acid (14:0) 1 acetyl-CoA → 1 succinate Please answer very soon will give rating surelyMany components of the glycolytic pathway and the citricacid cycle are direct exit or entry points to metabolic pathways ofother substances. Indicate another pathway available to the following compounds:(a) Fructose-6-phosphate(b) Oxaloacetate(c) Glucose-6-phosphate(d) Acetyl-CoA(e) Glyceraldehyde-3-phosphate(f) -Ketoglutarate(g) Dihydroxyacetone phosphate(h) Succinyl-CoA(i) 3-Phosphoglycerate(j) Fumarate(k) Phosphoenolpyruvate(l) Citrate(m) PyruvateFor myristic acid, C 13H 27CO 2H: (a) How many molecules of acetyl CoA are formed from complete β-oxidation? (b) How many cycles of β-oxidation are needed for complete oxidation?
- Which of the following is most helpful in ensuring that wasteful (unproductive) hydrolysis of acetyl CoA does not occur in the reaction catalyzed by citrate synthase? Group of answer choices Citrate synthase is a tetramer Induced fit ensures oxaloacetate binds before acetyl CoA 3 molecules of oxaloacetate bind for every 1 molecule of acetyl CoA Citrate inhibits the reaction Which of the following catalyzes a step that does NOT produce CO2? Group of answer choices alpha-ketoglutarate dehydrogenase complex malate dehydrogenase pyruvate dehydrogenase complex isocitrate dehydrogenase Citrate synthase is regulated by... Group of answer choices Concentrations of substrate and products Fructose-2,6-Bisphosphate Covalent modification Allosteric regulation by the levels of NADDHComplete the table below. Consider docosanoic acid (C21H43CO2H) Questions Show complete solutions Answers a. How many acetyl CoA molecules are formed by complete B-oxidation? b. How many cycles of B-oxidation are needed for complete oxidation? c. How many molecules of ATP are formed from the complete catabolism of this fatty acid?Consider oleic acid (18:1D9): How many rounds of beta oxidation will omit the enzyme acyl-CoA DH?