Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
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Chapter 23, Problem 16P
Extending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.
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The mechanism for the conversion from alpha kytoglutarate into succinyl CoA by alpha-ketoglutare dehydrogenase is analogous to the pyruvate dehydrogenase mechanism. Draw and show the major intermediates and arrow pushing for the enzyme-catalyze process for the conversion of alpha-ketoglutarate to succinyl CoA.
Note: the carbanion of thiamine pyrophosphate nucleophillically attacks C-2 of the alpha-ketoglutarate, i.e., the carbonyl carbon of that substrate.
For each of the central pathway intermediates given below, calculate how many ATP equivalents can be generated by complete oxidation of the compound to CO2:
1. Acetyl-CoA
2. Pyruvate
3. GAP (glyceraldehyde-3-phosphate)
And please explain why.
Consider the complete oxidation of one mole of arachidic acid (20:0).
___________ a. How many rounds of the β-oxidation pathway will be involved?
___________ b. How many acetyl CoA will be produced?
___________ c. How many NADH will be produced from all the rounds of the β-oxidation pathway?
___________ d. How many ATP will eventually be produced from the complete oxidation of one mole of arachidoyl CoA?
Chapter 23 Solutions
Biochemistry
Ch. 23 - Prob. 1PCh. 23 - Determining the Amount of ATP Produced from Fatty...Ch. 23 - Prob. 3PCh. 23 - Examining the Labeling of Glucose from 14C.labeled...Ch. 23 - Prob. 5PCh. 23 - Prob. 6PCh. 23 - Prob. 7PCh. 23 - Prob. 8PCh. 23 - Prob. 9PCh. 23 - Prob. 10P
Ch. 23 - Prob. 11PCh. 23 - Understanding Human Energy Consumption During...Ch. 23 - Prob. 13PCh. 23 - Prob. 14PCh. 23 - Prob. 15PCh. 23 - Extending the Mechanism of Methylmalonyl-CoA...Ch. 23 - Prob. 17PCh. 23 - Prob. 18PCh. 23 - Prob. 19PCh. 23 - Understanding a Ubiquitous Series of Metabolic...Ch. 23 - Using the ActiveModel for enoyl-CoA dehydratase,...
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- The Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.arrow_forwardExamine the ActiveModel for alcohol dehydrogenase and describe the structure and function of the catalytic zinc center.arrow_forwardCan you give me more expalination of Oxidation Deamination formation of -ketoglutaric acid and NH4+ from glutamate in the presence of glutamate dehydrogenase What is the rule for glutamate to oxaloacetate to form α-ketoglutarate and aspartate?arrow_forward
- Predict which one of the five steps of the α-ketoglutarate dehydrogenase complex reaction is metabolically irreversible under physiological conditions and explain why.arrow_forwardConsider the hypothetical reaction plot of salivary α-amylase shown below: a. Determine whether the plot describes substrate disappearance or product formation. Using Equation 5-2, express the rate of reaction described by the plot.b. Based on the plot, determine the time interval at which the rate of reaction must be measured.arrow_forwardIn the complete b-oxidation of stearic acid (18:0) How many moles of acetyl CoA are produced? How many times would the fatty acid pass through the fatty acid spiral for complete oxidation?arrow_forward
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