4. Provide a detailed, stepwise mechanism for the following reaction. NO₂ NO₂ + OCH, OCH, NO₂ NO₂ F

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter24: Catalytic Carbon-carbon Bond Formation
Section: Chapter Questions
Problem 24.22P
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4. Provide a detailed, stepwise mechanism for the following reaction.
Ph Ph
Ph-P
Pdº +
Ph-P
Ph Ph
A
5. Show the intermediates for the following steps of the catalytic cycle for the Suzuki cross-coupling
reaction.
Br
+
oxidative
addition
Br
NO₂
B
HO OH
NO₂
+ OCH₂
transmetallation
SNa
OCH,
NO₂
NO₂
NaOH (aq)
ligand
exchange
F
B(OH)3 is a byproduct of this step
Ph Phi
Ph-P
Pd"
Ph-POH
Ph Ph
reductive
elimination
6. Provide a detailed, stepwise mechanism for the following reaction. What is the correct designation fo
this type of substitution reaction?
S.
A
Designation
CH3
Transcribed Image Text:4. Provide a detailed, stepwise mechanism for the following reaction. Ph Ph Ph-P Pdº + Ph-P Ph Ph A 5. Show the intermediates for the following steps of the catalytic cycle for the Suzuki cross-coupling reaction. Br + oxidative addition Br NO₂ B HO OH NO₂ + OCH₂ transmetallation SNa OCH, NO₂ NO₂ NaOH (aq) ligand exchange F B(OH)3 is a byproduct of this step Ph Phi Ph-P Pd" Ph-POH Ph Ph reductive elimination 6. Provide a detailed, stepwise mechanism for the following reaction. What is the correct designation fo this type of substitution reaction? S. A Designation CH3
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