4. You are to choose the members of an expedition that will climb several high mountains. Each applicant for one of the positions is a heterozygote for an abnormal hemoglobin: Person A: Hb Albany: a methionine has been substituted for Lys 82 in the ß-subunit. Person B: Hb Cowtown: a leucine has been substituted for His 146 in the ß-subunit. Person C: Hb Flagstaff: an isoleucine has been substituted for Val 1 in the ß-subunit. For the locations of the amino acid residues refer to your text, the figure on page 9 of this lab, and the KiNG exercises. Assuming that each of these candidates is equal in ability at low altitude, which one would you choose for the expedition? To answer this question, determine how the substituted amino acid affects the structure and function of each abnormal hemoglobin, and describe the physiological effect. Focus on the stabilization of the T versus R state of hemoglobin, and the consequent physiological changes that might occur at high altitude. Keep your answers brief. Person A Person B Person C
4. You are to choose the members of an expedition that will climb several high mountains. Each applicant for one of the positions is a heterozygote for an abnormal hemoglobin: Person A: Hb Albany: a methionine has been substituted for Lys 82 in the ß-subunit. Person B: Hb Cowtown: a leucine has been substituted for His 146 in the ß-subunit. Person C: Hb Flagstaff: an isoleucine has been substituted for Val 1 in the ß-subunit. For the locations of the amino acid residues refer to your text, the figure on page 9 of this lab, and the KiNG exercises. Assuming that each of these candidates is equal in ability at low altitude, which one would you choose for the expedition? To answer this question, determine how the substituted amino acid affects the structure and function of each abnormal hemoglobin, and describe the physiological effect. Focus on the stabilization of the T versus R state of hemoglobin, and the consequent physiological changes that might occur at high altitude. Keep your answers brief. Person A Person B Person C
Biology: The Dynamic Science (MindTap Course List)
4th Edition
ISBN:9781305389892
Author:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Publisher:Peter J. Russell, Paul E. Hertz, Beverly McMillan
Chapter15: From Dna To Protein
Section: Chapter Questions
Problem 4TYK
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