5) Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4). Radioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared to I-131. (Taken from https://pubchem.ncbi.nlm.nih.gov/compound/Iodide-ion-I-123) a) Provide a balance reaction for 123I undergoing electron capture. b) You are having a thyroid study done and are injected with a sodium iodide solution. To image the thyroid they usually wait 20 minutes. What % of the radioisotope (and this the radioactivity) remain in your body 24 hours after the injection? c) 123I nucleus weighs 122.905589 g per mole. What is the mass defect for the atom? Use 1.008664 amu as the weight of a neutron and 1.007276 amu as the weight of the proton. d) Using the mass defect calculate the binding energy in units of J per nucleon

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter9: Nuclear Chemistry

Section: Chapter Questions

Problem 9.50P

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5) Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123. Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4). Radioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared to I-131. (Taken from https://pubchem.ncbi.nlm.nih.gov/compound/Iodide-ion-I-123)

a) Provide a balance reaction for ¹²³I undergoing electron capture.

b) You are having a thyroid study done and are injected with a sodium iodide solution. To image the thyroid they usually wait 20 minutes. What % of the radioisotope (and this the radioactivity) remain in your body 24 hours after the injection?

c) ¹²³I nucleus weighs 122.905589 g per mole. What is the mass defect for the atom? Use 1.008664 amu as the weight of a neutron and 1.007276 amu as the weight of the proton.

d) Using the mass defect calculate the binding energy in units of J per nucleon.

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