5. Acetaminophen (Tylenol™) is a common NSAID but is hepatotoxic in high doses. It is therefore veryimportant to excrete this xenobiotic from our bodies. Phase II Drug metabolism does this byconjugating the molecule with Glucuronic acid. Choose true statements for this organic reaction:Phase lI: Glucuronidation(Conjugation)vー4(UDPGA]ноноUGTонacetaminophen glucuronideENZ-B:ENZ = Enzyme:UDP-glucuronyitransferase (UGT)но.ноно.онUridine diphosphate glucuronic acidabbrv.: UDP-Glucuronic acid (ÚDPGA); "activated" Glucuronic acidI: Glucuronidation, i.e., adding glucuronic acid to a molecule, makes it more water-soluble.II: The phenol of acetaminophen is now part of an acetal as the glucuronide product.III: Glucuronic acid has a pKa of 3.21 and will be primarily protonated at physiological pH = 7.40.IV: Activated glucuronic acid (UDPGA) has a good diphosphate leaving group.V: This biotransformation would be classified as an oxidation reaction.[a] I, IV, & V[b] III & V[c] I, II, IV & V[d] I, II & IV[e] I& IV

The metabolism of several drugs depends on their solubility in the aqueous environment of the body.…

5. Acetaminophen (Tylenol™) is a common NSAID but is hepatotoxic in high doses. It is therefore very important to excrete this xenobiotic from our bodies. Phase II Drug metabolism does this by conjugating the molecule with Glucuronic acid. Choose true statements for this organic reaction: Phase I: Glucuronidation (Conjugation) (UDPGA) но но. UGT он acetaminophen glucuronide ENZ-B! ENZ = Enzyme: UDP-glucuronyitransterase (UGT) но. HO но- он Uridine diphosphate glucuronic acid abbrv.: UDP-Glucuronic acid (UDPGA); “activated" Glucuronic acid I: Glucuronidation, i.e., adding glucuronic acid to a molecule, makes it more water-soluble. II: The phenol of acetaminophen is now part of an acetal as the glucuronide product. III: Glucuronic acid has a pKa of 3.21 and will be primarily protonated at physiological pH = 7.40. IV: Activated glucuronic acid (UDPGA) has a good diphosphate leaving group. V: This biotransformation would be classified as an oxidation reaction. [a] I, IV, & V [b] III & V [c] I, II, IV & V [d] I, II & IV [e] I& IV

5. Acetaminophen (Tylenol™) is a common NSAID but is hepatotoxic in high doses. It is therefore very important to excrete this xenobiotic from our bodies. Phase II Drug metabolism does this by conjugating the molecule with Glucuronic acid. Choose true statements for this organic reaction: Phase I: Glucuronidation (Conjugation) (UDPGA) но но. UGT он acetaminophen glucuronide ENZ-B! ENZ = Enzyme: UDP-glucuronyitransterase (UGT) но. HO но- он Uridine diphosphate glucuronic acid abbrv.: UDP-Glucuronic acid (UDPGA); “activated" Glucuronic acid I: Glucuronidation, i.e., adding glucuronic acid to a molecule, makes it more water-soluble. II: The phenol of acetaminophen is now part of an acetal as the glucuronide product. III: Glucuronic acid has a pKa of 3.21 and will be primarily protonated at physiological pH = 7.40. IV: Activated glucuronic acid (UDPGA) has a good diphosphate leaving group. V: This biotransformation would be classified as an oxidation reaction. [a] I, IV, & V [b] III & V [c] I, II, IV & V [d] I, II & IV [e] I& IV

Biology 2e

2nd Edition

ISBN:9781947172517

Author:Matthew Douglas, Jung Choi, Mary Ann Clark

Publisher:Matthew Douglas, Jung Choi, Mary Ann Clark

Chapter6: Metabolism

Section: Chapter Questions

Problem 7RQ: Which of the following comparisons or contrasts between endergonic and exergonic reactions is false?...

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