Could you help me with this question? I don't know where to start. All the information has been provided. REFER TO THE SCHEME FOR THE SYNTHESIS OF LIDOCAINE SHOWN BELOWNO2 SnCl,/ HCINH3 CINH2КонCH,COOHCH;COOH1232,6-Dimethy-2,6-Dimethy-nitrobenzeneanilineHtoluene5a-Chloro-2,6-Lidocainedimethylacetanilide 5. In the reaction below, what factors come into play to favor attack of the aniline 3 on the carbonylcarbon of the acid chloride (carbon 1 in red), rather than at the a-carbon (carbon 2 in red)?LNH22

Solution : Nucleophilic addition reaction is that reaction in which nucleophile(electron-rich…

5. In the reaction below, what factors come into play to favor attack of the aniline 3 on the carbonyl carbon of the acid chloride (carbon 1 in red), rather than at the a-carbon (carbon 2 in red)? „NH2 3

5. In the reaction below, what factors come into play to favor attack of the aniline 3 on the carbonyl carbon of the acid chloride (carbon 1 in red), rather than at the a-carbon (carbon 2 in red)? „NH2 3

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.68P: Show how the synthetic scheme developed in Problem 23.67 can be modified to synthesize this...

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Question

Could you help me with this question? I don't know where to start. All the information has been provided.

REFER TO THE SCHEME FOR THE SYNTHESIS OF LIDOCAINE SHOWN BELOW
NO2 SnCl,/ HCI
NH3 CI
NH2
Кон
CH,COOH
CH;COOH
1
2
3
2,6-Dimethy-
2,6-Dimethy-
nitrobenzene
aniline
H
toluene
5
a-Chloro-2,6-
Lidocaine
dimethylacetanilide

5. In the reaction below, what factors come into play to favor attack of the aniline 3 on the carbonyl
carbon of the acid chloride (carbon 1 in red), rather than at the a-carbon (carbon 2 in red)?
LNH2
2

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