7. In the ketone body pathway, both acetoacetate and B-hydroxy butyrate are produced and become additional fuel molecules for the organism. a. Define where these molecules are produced (both tissue type and location in the cell) and what tissue they "feed". b. Of these two molecules, which one is considered slightly better in delivering more energy to the target tissue? Why? c. How does acetone, another ketone body, participate in delivering fuel to target tissue? d. If acetoacetate decarboxylase enzyme was mutated and became inactive (zero enzyme activity), how would this affect the ketone pathway during these conditions: į. immediately after a meal, ii. under starvation conditions, iii. during unchecked (not being treated for) type-1 diabetes.
7. In the ketone body pathway, both acetoacetate and B-hydroxy butyrate are produced and become additional fuel molecules for the organism. a. Define where these molecules are produced (both tissue type and location in the cell) and what tissue they "feed". b. Of these two molecules, which one is considered slightly better in delivering more energy to the target tissue? Why? c. How does acetone, another ketone body, participate in delivering fuel to target tissue? d. If acetoacetate decarboxylase enzyme was mutated and became inactive (zero enzyme activity), how would this affect the ketone pathway during these conditions: į. immediately after a meal, ii. under starvation conditions, iii. during unchecked (not being treated for) type-1 diabetes.
Organic And Biological Chemistry
7th Edition
ISBN:9781305081079
Author:STOKER, H. Stephen (howard Stephen)
Publisher:STOKER, H. Stephen (howard Stephen)
Chapter14: Lipid Metabolism
Section: Chapter Questions
Problem 14.45EP
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