A 10-mL aqueous solution of acetaminophen was extracted with 10 mL of octanol. The initial aqueous solution had an absorbance of 0.971 after 600 µL was diluted with 1400 µL of water. After extraction, undiluted aqueous phase had an absorbance of 1.047. Find Kow of acetaminophen.
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- The solubility of suberic acid C6H12(COOH)2 is 0.14 g/100 ml H2O and 0.56g/100 ml ethyl ether at 15 0C. Calculate the weight of suberic acid removed from 50 ml aqueous solution containing 40 mg acid by extraction with 50 ml ether. Calculate the weight of acid that would be removed by two successive 25 ml extraction with ether.10g coffee 4g sodium carbonate 40m dichloromethane 160ml distilled water coffee filter What are the principles behind caffeine being extracted from coffee using the above items? 1st sodium carbonate mixed with coffee then brought to a boil for 20min then solution/grinds are filtered. Then solution is added to a separatory funnel with 15ml of dichloromethane and two layers are observed so the bottom layer with DCM contains the caffeine, then this layer is collected in a beaker and dried out using molecular seeds. Then the solvent is brought to a boil with crude caffeine remaining and recystallized using 95% ethanol and brought to a boil again. Then the contents are vaccum filtered and allowed to dry resulting in 30mg caffeine.An organic compound has a distribution coefficient of 1.5 in methylene chloride and water. If 50 mg of this compound is dissolved in 15 mL of water, in which case will more of the compound be extracted into the methylene chloride: one extraction with 15 mL of methylene chloride or three extractions using 5 mL of methlene chloride each time? Show all work.
- 1. Why should the stopper always be removed from a separatory funnel whenever a liquid is being drained through the stopcock?2. The distribution coefficient, KD (ether/water), between ether and water for aspirin at room temperature is 3.5. What weight of aspirin would be extracted by a single extraction with 60 ml of water from a solution of 10 grams of aspirin in 100 ml of ether? Calculate the weight of aspirin which would be removed by three extractions with 20 ml portions of water.3. Assume that in extraction from water into toulene, analyte A has distribution ratio of 10. A 20 mL portion of an aqueous solution of A is extracted with toulene. Which of thw following procedures will result in most efficient removal of A from the aqueous phase into toulene? (Please show the solution of the correct answer) A. 1 extraction with 20 mL of touleneB. 1 extraction with 40 mL of touleneC. 2 extractions with 20 mL of toulene eachD. 4 extractions with 10 mL of toulene each20 tablets containing the dibasic drug ethambutol hydrochloride (MW 277.2 g/mol) were powdered. 0.3354 g of tablet powder was dissolved in 10 mL of 2 M sodium hydroxide and was extracted with 5 x 25 mL quantities of chloroform. The combined extracts were evaporated and the residue was dissolved in 100 mL of anhydrous acetic acid. Non-aqueous titration was carried out using 1-naphtholbenzein solution as indicator and 0.1014 M acetous perchloric acid. Volume of acetous perchloric acid required = 14.2 mL, weight of 20 tablets = 3.367 g, state content of ethambutol hydrochloride per tablet = 100 mg. Calculate the % of stated content in the tablets.
- A 25 g of butyric acid was extracted with 400 mL ether from 400 mL water (Kd=3.0 at 25 °C) Using single-step extraction, what is the amount of butyric acid in water layer? What is the total amount of butyric acid extracted using two successive extractions? Calculate the % efficiency of two-step extraction over singleYou have a MASTER STOCK solution containing 1.000g of caffeine in 100mL of mobile phase solvent mixture (20% methanol / 80% water with a formic acid sodium formate buffer @ pH 3.4) You have a diluted STUDENT STOCK solution that contains 0.01g of caffeine in 100mL of mobile phase solvent mixture. You are asked to prepare 3 diluted concentrations: 1. 15 mL of student stock in 25 mL of mobile phase solvent. 2. 10 mL of student stock in 25 mL of mobile phase solvent. 3. 5 mL of student stock in 25 mL of mobile phase solvent. Calculate the concentration of caffeine (in mg/mL) for each dilution.From a 10-mL sample, a 1-mL aliquot was taken and diluted to 100mL. From this, a 5-mL aliquot was taken and diluted to 20mL.The final 20mL was found to have a concentration of 0.004M analyte X.What is the concentration of analyte X in the 10-mL sample?
- 11. How much caffeine can be extracted using 50.0ml of DCM if a tea bag contains 15 grams of tea leaves with 0.9% of caffeine? And has undergone solid-liquid extraction with 100ml of distilled water followed by liquid-liquid extraction using DCM. The solubility of caffeine requires 15 ml of water and 2.0ml of DCM for 40.0mg. a 6.1 x 10^-5 b 6.0 x 10^-5 c 7.0 x 10^-5 d 7.1 x 10^-5Please answer all 5 questions (it could be short answers). 5-1. What is the main barrier to separating liquid mixtures of less than 500 mL by distillation? 5-2. A sample mixture of ethyl benzoate (bp 212 Celsius) and dodecane (bp 216.2 Celsius) is injected on two GC columns. Column A has DC710 silicone oil as the stationary phase, and column B uses polyethylene glycol as the stationary phase. Which substance would be certain to elute first from column A and would the same material be expected to elute first from column B? Which column, A or B, would be expected to give the better separation of these two substances? 5-3. Question 5-2 refers to separating a mixture of two high boiling liquids by gas chromatography. These materials have similar boiling points. List several GC variables and conditions that would make it easier to separate thesesubstances by gas chromatography 5-4. Capillary GC columns have better resolution than packed columns even though the enormous surface area…15 g of unknown organic sample was dissolve in 575 mL of Dicloromethane (DCM). The boiling point of benzene was increased by 3.40oC. Determine the molecular weight of the unknown sample? Kb of DCM = 2.42oC/m Bb of benzene = 39.6 oC density of benzene = 1.33 g/mL at 25 °C
