A 160 residue polytopic integral plasma membrane protein has the following sequence at its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11- 14 are localized outside the cell. N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp- Ile-His-Leu-23 Ser-Gly-Gly Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure of the entire 160 residue protein? (b) Give at least three reasons for your prediction. Ruling out alternatives, with proper logic, can count as a reason.

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter9: Gene Expression And Gene Regulation
Section: Chapter Questions
Problem 18QP: The following is a portion of a protein: met-trp-tyr-arg-gly-pro-thr-Various mutant forms of this...
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A 160 residue polytopic integral plasma membrane protein has the following sequence at
its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11-
14 are localized outside the cell.
N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp-
Ile-His-Leu-23 Ser-Gly-Gly
Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure
of the entire 160 residue protein? (b) Give at least three reasons for your prediction.
Ruling out alternatives, with proper logic, can count as a reason.
Transcribed Image Text:A 160 residue polytopic integral plasma membrane protein has the following sequence at its N-terminus. The amino terminal Ser is located inside the cytoplasm. Amino acids 11- 14 are localized outside the cell. N-¹Ser-Tyr-Leu-Gln-Ile-Arg-Phe-Asn-Leu-Lys-11 Gly-Pro-Gly-Ser-15 Glu-Phe-Gln-Leu-Asp- Ile-His-Leu-23 Ser-Gly-Gly Carefully analyze the sequence. (a) What do you predict for the overall tertiary structure of the entire 160 residue protein? (b) Give at least three reasons for your prediction. Ruling out alternatives, with proper logic, can count as a reason.
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