A 6-year-old boy is brought to the physician by his mother because of intermittent upper abdominal pain during the past 5 weeks and a rash for 1 week. Vital signs are normal. Physical examination shows yellow nodules over the extensor surfaces of the upper extremities. There's hepatomegaly and tenderness on palpation of the epigastric region. Serum studies show an increased amylase activity, increased chylomicron concentration, and a markedly increased triglyceride concentration. 3 months after beginning a fat-restricted diet, his serum chylomicron and triglyceride concentration decreased significantly, and the skin lesions resolve. A deficiency of which of the following enzymes is the most likely cause of these findings? a. Acetyl-CoA carboxylase b. HMG-CoA lyase c. HMG-CoA reductase d. Hormone-sensitive lipase e. Lipoprotein lipase
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