a) Compound 1 is a nonsteroidal anti-inflammatory (NSAID) drug. Knowing that its thiazole ring can be synthesised using Hantzschs method, propose the structure of the thioamide (2) and a-haloketone (3) fragments that take part in the reaction CI соон 1 2 3 b) Explain the reason why in the Hantzscb's synthesis of thiazoles the sulfur atom of the thioamide moiety prefers to attack the carbon-halogen bond while the nitrogen atom attacks the carbonyl group and not the other way around.
a) Compound 1 is a nonsteroidal anti-inflammatory (NSAID) drug. Knowing that its thiazole ring can be synthesised using Hantzschs method, propose the structure of the thioamide (2) and a-haloketone (3) fragments that take part in the reaction CI соон 1 2 3 b) Explain the reason why in the Hantzscb's synthesis of thiazoles the sulfur atom of the thioamide moiety prefers to attack the carbon-halogen bond while the nitrogen atom attacks the carbonyl group and not the other way around.
Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter23: Amines
Section: Chapter Questions
Problem 23.37P
Related questions
Question
Expert Solution
This question has been solved!
Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.
This is a popular solution!
Trending now
This is a popular solution!
Step by step
Solved in 2 steps with 2 images
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.Recommended textbooks for you
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning