A) describe in molecular detail how protonation of the histidine side-chain results in hemoglobin's lower affinity for oxygen. b) what value do you expect for the pKa of the histidine side-chain ionizable group?

Human Heredity: Principles and Issues (MindTap Course List)
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ISBN:9781305251052
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Chapter10: From Proteins To Phenotypes
Section10.7: Defects In Transport Proteins: Hemoglobin
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A) describe in molecular detail how protonation of the histidine side-chain results in hemoglobin's lower affinity for oxygen.

b) what value do you expect for the pKa of the histidine side-chain ionizable group?

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