Give the effect of the following changes in the protein structure of hemoglobin Replacement of analanine located at the middle of helix B with proline
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- Shown in the following table are several amino acid substitutionsin the a and b chains of human hemoglobin. determine how many of them can occur as a result of a single nucleotide change.Why proline encounters at the myoglobin and hemoglobin molecules where polypeptide chains turns a corner?how do salt bridges that include amino-terminal carbamate stabilize the deoxy form of hemoglobin. Please answer it asap.... With detailed explanation...
- The following sequence of amino acids are part of adult hemoglobin from the N-terminus. DRAW THE STRUCTURE OF THIS PEPTIDE. Val-His-Leu-Thr-Pro-Glu-Glu-Lys-Ser-Ala-Val-ThrConsidering the chemical characteristics of the amino acids valine and glutamic acid (see Figure 5.14), propose a possible explanation for the dramatic effect on protein function that occurs when valine is substituted for glutamic acid.if the tetrapeptide shown in the binding site above (Gly-Ser-His-lle) were in an aqueous solution at pH=6.2, what fraction of peptide molecules would have a +1 charge?
- In some proteins, the side chain of serine appears to undergo ionization. Explain why ionization would be facilitated by the presence of an aspartate residue nearby.In pyrimidine nucleosides the anti conformation predominates because of steric interactions with pentose. Do thepurine nucleosides have similar interactions?you have the following peptide Arg-Ile-Pro-Leu-Asp-Lys-Glu The net charge on this peptide at pH 7.0 is ?. The net charge on this peptide at 1M HCl is ?.
- The following sequence of amino acids are part of adult hemoglobin from the N-terminus. Draw the skeletal structure of this peptide. Val-His-Leu-Thr-Pro-Glu-Glu-Lys-Ser-Ala-Val-Thrdraw the structure of the tripeptife Pro-Ser-Cys as it would appear at physiological PH with its C-terminal amino acid residue protected as its methyl esterIn the following polypeptide, which amino acid would be participating in hydrogen bonding with alanine, given this sequence forms an alpha helix? Please write out the full amino acid name, not the abbreviation. Met-Ala-Leu-Glu-Lys-Thr-Leu-Val