a) In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Post-administration of mitoxantrone to sedentary and exercised groups smaller patches of demyelination with microcyst formation and lymphocytic infiltrates were seen; and bare unmyelinated axons were fewer (Figs. 3D, E, I, J and 4D, E, I, J).” Based on this quote, what is mitoxantrone doing exactly/directly? b) In the histopathological study section of the materials and methods section the authors wrote “Luxol fast blue (LFB) staining was used for assessment of demyelination in the cerebellum and brain stem and scored as described previously by Zhang et al. [21] and illustrated in Table 2.” Why was demyelination assessed in this study?
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https://doi.org/10.1186/s12868-022-00692-1 (link to research)
a) In the effect of mitoxantrone on histopathological changes in the brain section of the results section the authors wrote “Post-administration of mitoxantrone to sedentary and exercised groups smaller patches of demyelination with microcyst formation and lymphocytic infiltrates were seen; and bare unmyelinated axons were fewer (Figs. 3D, E, I, J and 4D, E, I, J).” Based on this quote, what is mitoxantrone doing exactly/directly?
b) In the histopathological study section of the materials and methods section the authors wrote “Luxol fast blue (LFB) staining was used for assessment of demyelination in the cerebellum and brain stem and scored as described previously by Zhang et al. [21] and illustrated in Table 2.” Why was demyelination assessed in this study?
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