Why is the use of first-generation H1-antihistamines discouraged in clinical practice today?

Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter3: Basic Hemostasis
Section3.4: Prothrombin Time
Problem 8RQ
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Why is the use of first-generation H1-antihistamines discouraged in clinical practice today? 

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