A mutation of Lysine 82 (in the DPG-binding pocket) to Arginine in beta sub-unit will most likely result in Not enough information Higher than normal binding affinity to oxygen Lower than normal binding affinity to oxygen Normal binding to oxygen

A mutation of Lysine 82 (in the DPG-binding pocket) to Arginine in beta sub-unit will most likely result in Not enough information Higher than normal binding affinity to oxygen Lower than normal binding affinity to oxygen Normal binding to oxygen

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 19QP: A person was found to have very low levels of functional beta globin mRNA and therefore very low...

See similar textbooks

Related questions

Q: Which statement about the glycoprotein shown below is true? OH CH₂OH OH HN HN-C O CH3 H₂ Protein CH…

A: Chemically, carbohydrates are polyhydroxy aldehydes or ketones. Monosaccharides are single unit…

Q: Determine whether each of the examples or phrases describes an essential amino acid, a nonessential…

A: Amino acids are the monomer units of proteins. Out of the 20 general proteogenic amino acids, some…

Q: Refer to the figure shown here, and determine the value of E for the overall oxidation/reduction…

A: The reactions in which the electrons are transferred from one substance to the other substance are…

Q: Consider a protein in which a negatively charged glutamic acid side chain (pKa=4.2) makes a salt…

A: Salt bridges are attractive interactions between two oppositely charged groups. So, more oppositely…

Q: For an enzyme obeying the Michaelis-Menten equation with Km = 5 µM, kcat = 10 s-l and a total enzyme…

A: Since you have posted multiple questions, we will provide the solution only to the specified sub…

Q: Part C If AH = -80.0 kJ and AS = -0.400 kJ/K, the reaction is spontaneous below a certain…

Q: Previously Protein A and 5mM of ligand X were combined in a neutral solution and 36% of Protein A…

A: In this scenario, we are comparing how Protein A interacts with ligand X under two different…

Q: Some microbes like E. Coli have flexible metabolic systems that allow them to generate energy under…

A: E.coli can undertake both aerobic and anaerobic respiration to generate ATP (energy). ATP is…

Q: What would happen to the rate of glycolysis if there were high levels of pep in the cytosol of the…

A: Glycolysis is a collection of 10 enzymatically catalysed reactions that sequentially oxidise a…

Q: Draw the structure of lysine in the protonation state that would predominate at pH 9.5.

A: Amino acids are the building blocks of polypeptides and proteins.Humans have 20 different amino…

Q: A researcher synthesizes a new molecule called inhibitor X that inhibits the activity of…

A: When a substrate (S) binds to the active site of an enzyme (E), it leads to the formation of an ES…

Q: The equilibrium constant of a system, K, can be related to the standard free energy change, AG,…

A: Details

Q: Mixtures of amino acids can be analyzed by first separating the mixture into its components through…

A: At a pH of 7, the side chain of some of the amino acids will be positively charged, some will be…

Q: Addition of immunoglobulin G (IgG) specific for hemoglobin to a solution of hemoglobin results in…

A: Antibodies are proteins that are produced by the immune system to recognize and neutralize foreign…

Q: Use the polygon to draw the MO energy diagram for:

A: Here we can see the structure of Cyclotetraene with two lone pairs.The no. of pi electrons in…

Q: During a test for lipids,why do you think one has to place the sample in a dry test tube

A: Lipids are a chemically diverse group of biomolecules that have two things in common:low solubility…

Q: Below is a U-tube experiment with a membrane that is selectively permeable to water, but does not…

A: Here we are using a U-tube. The height of water column in both tubes are the same, so the force…

Q: Glycine Alanine Valine Leucine Isoleucine Name Structure 1-Let Abbr 3-Let Abbr Class (non-polar,…

A: Amino acids are organic compounds that form the building blocks of proteins in cells. The structure…

Q: The tripeptide Glu-Pro-Arg (EPR) which is a product of Lactobacillus casei fermentation of milk was…

A: A peptide is a name assigned to short polymers of amino acids that are less than 50. Tripeptide is…

Q: Please draw the structure of the 19 L-a-amino acids and proline in any form, as you prefer. You may…

A: Amino acids serve as monomers of proteins and composed of a carboxyl group, an amino group, a…

Q: Molly is a 10-year-old girl of short stature with hyperelastic skin which bruises easily, and…

A: 1. Amount of Vitamin C in Jane’s diet fails to improve Jane’s symptoms because the dermatosparaxis…

Q: Name the two most common atoms hydrogen bonds within biological systems that give hydrogen a partial…

A: Hydrogen bond is formed between a hydrogen atom which is bonded to an electro negative atom( donor)…

Q: All amino acids have two ionizable functional groups: an a-amino group (average pK₁ of 9.4) and an…

A: Amino acids are biomolecules that have an amino group and a carboxyl group linked to the same carbon…

Q: Which of the reactions are spontaneous (favorable)? L-malate + NAD+ oxaloacetate + NADH + H+ AG =…

A: Gibbs free energy change (ΔG) is a thermodynamic quantity that represents the maximum reversible…

Q: What are the pathways used in the production of secondary metabolites present in flavonoids (Present…

A: Flavonoids belong to the class of secondary metabolites in plants. They have a poly phenolic…

Q: A lysine is burined inside a protein surrounded by hydrophobic resiudes, how does this affect the…

A: Answer :- The behavior of amino acid residues within a protein is profoundly influenced by their…

Q: Explore the advancements in packaging technology, including aseptic packaging and vacuum packaging,…

A: By shielding food from physical, chemical, and microbiological harm, effective packaging is crucial…

Q: Macm Determine the charge of the peptide at pH 5.5. -2 O -1 0 +1 +2 Determine the charge of the…

A: H |H-N-C-COOH | | H HIn this structure, both the amino group of Glycine…

Q: 1. The peptide below was isolated from fermented milk and shown to have antioxidant properties…

A: Since you have posted a question with multiple sub parts, we will provide the solution only to the…

Q: The hydrolysis of phosphate bonds provides the chemical energy to drive reactions in the cell. The…

A: Gibbs free energy of hydrolysis of creatine phosphate to creatine isΔG°= -43kJ/molThis implies, its…

Q: The following is a segment of the primary structure of an α-helix: N terminus.......– amino acid 1…

Q: The amino acid at the β82 position is in the central cavity that binds 2,3-bisphosphoglycerate in…

A: Asparagine is a neutral amino acid while lysine is positively charged amino acid. Lysine being in…

Q: In an ammonia molecule, one nitrogen atom (atomic number = 7; 1s² 2s²2p³) forms covalent bonds with…

A: Ammonia (NH3) is a colourless gas with a strong odour that is made up of one nitrogen atom coupled…

Q: 3) After watching the video convert the monosaccharides from a Fischer to a Haworth Projection. c)…

A: Fischer and Haworth ProjectionsFischer and Haworth projections are two ways of representing the…

Q: Complete the data missing from the table, which shows assay data from the purification protocol of a…

A: A protein purification assay will include multiple protein purification techniques, conducted one…

Q: Chymotrypsin, trypsin, and elastase are digestive enzymes called serine proteases. The serine…

A: Aminoacids are classified based on the nature of their side chain. They areAcidic aminoacids :…

Q: Beta-sheets are roughly planar structures, in which the backbone hydrogen bonding pattern defines…

A: Beta sheet is the secondary structure of a protein that is formed by the hydrogen bonds between the…

Q: What characteristics determine the position of a protein on an IPG strip at the end of isoelectric…

A: Isoelectric focussing is a technique used for the separation of biomolecules, particularly proteins,…

Q: ou have been researching two additional methyltransferase enzymes that catalyze the same reaction.…

A: For a one-substrate enzyme-catalyzed reaction, the Michaelis-Menton equation shows the quantitative…

Q: Recall that when we calculated the fraction of estrogen receptors occupied in the presence of 1 nM…

A: To calculate the concentration of free receptor (Rfree) in terms of the total concentration of…

Q: In cytosol Enzyme 1 Enzyme 2 In mitochondria CH₂(CH₂) COOH A B C TI F F DE D E +ATP + PP₁

A: Beta-oxidation is the catabolic pathway by which fatty acids are catabolised into acetyl coA…

Q: Determine whether each of the examples or phrases describes an essential amino acid, a nonessential…

A: Amino acids are the building blocks of proteins, which are essential molecules in living organisms.…

Q: Please draw the structure of the 19 L-a-amino acids and proline in any form, as you prefer. You may…

A: Amino acids are the monomer units that make up polypeptides, that eventually folds to become…

Q: How would the following enzymes speed up or slow down glycolysis? - high levels of Amp - high levels…

A: In glycolysis, a 6-carbon molecule of glucose-6-phosphate is broken down into 3-carbon pyruvate. It…

Q: It is necessary to purify the enzyme before the characterization process?

A: Amazing biological molecules called enzymes catalyze biochemical reactions in living organisms.…

Q: The phrase "dietary amino acids are absorbed during digestion" is used to describe when: Amino acids…

A: Amino acids combine to form proteins. Proteins and amino acids are the building blocks of life.…

Q: Protein aldolase cytochrome c pyruvate kinase lactate dehydrogenase ornithine decarboxylase…

A: In isoelectric focusing, protein separation is based on the isoelectric point (pI). pI is the pH…

Q: Energy Conversion Problem 1. a) Influence of concentration on the free energy change. In frog…

Q: Balance the basic equation of oxidative metabolism.

A: Oxidative metabolism is a fundamental biochemical process that occurs within cells to generate…

Q: Why is the net charge 0 for cooh? Shouldn't it be +1?

A: Amino acids are biomolecules that have an amino group, a carboxyl group and a side group that is…

Question

A mutation of Lysine 82 (in the DPG-binding pocket) to Arginine in beta sub-unit will
most likely result in
Not enough information
Higher than normal binding affinity to oxygen
Lower than normal binding affinity to oxygen
Normal binding to oxygen

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1: Mutation definition

VIEW

Step 2: Correct option explanation

VIEW

Step 3: Incorrect options explanation

VIEW

Solution

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 4 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

In oxygenated hemoglobin, pKa 5 6.6 forthe histidines at position 146 on the -chain. In deoxygenated hemoglobin, the pKa of these residues is 8.2. How can this piece ofinformation be correlated with the Bohr effect?
A mutation of Lysine 82 (in the DPG-binding pocket) to Arginine in beta sub-unit will most likely result in a) Not enough information b) Normal binding to oxygen c) Higher than normal binding affinity to oxygen d) Lower than normal binding affinity to oxygen
A new oxygen transport protein that exhibits cooperative binding has been isolated and is beingstudied in the lab. Calculate the KD value if Y = 0.76 when pO2 = 18 torr (assume n = 2.5). Howdoes this compare to the KD value for hemoglobin? Does this protein bind more or less tightly tooxygen compared to hemoglobin?
A protein-ligand binding reaction is run. At equilibrium, half the protein is ligand bound, the unboundligand concentration is 0.657 nM. Calculate the koff value for this reaction. Assume the kon value is typical ofprotein-ligand interactions.
(No more than one page). Explain why quaternary structure is necessary for cooperativity and allosteric regulation. Use hemoglobin as an example. Include the various allosteric effectors that influence oxygen binding.
The transport of aspirin (pKa = 3.5, structure shown here) from the digestive tract to the circulation occurs by nonmediated absorption into cells lining the stomach (where pH = 0.8) and the small intestine (where pH 6.0). Do you expect absorption to be faster in the stomach or in the small intestine?
The following sequence of amino acids are part of adult hemoglobin from the N-terminus. Draw the skeletal structure of this peptide. Val-His-Leu-Thr-Pro-Glu-Glu-Lys-Ser-Ala-Val-Thr
You have a mixture of 4 amino acids (Q, W, E, R, T) that you want to separate using ion exchange chromatography. Which of these amino acids would bind most strongly to a DEAE anion exchange column at pH 7? Q W E R T
What is the fractional occupancy of a protein binding site when the ligand concentration (L) =1mM and the ligand equilibrium binding constant at the binding site K10= 10microM. 0.01 B.0.1 C.0.91 D.0.99 none of the listed values
how do salt bridges that include amino-terminal carbamate stabilize the deoxy form of hemoglobin. Please answer it asap.... With detailed explanation...
Calculate the concentration of the ligand required to fill 25% of the binding site. X+A ⇌ XA , ka = 1.5 ×10-6 Y+A ⇌ YA , ka = 4.7 × 10-4 (i.e, q = 0.25) for both proteins.
The production of arginine is terminated by the presence of excess arginine. State which phenomenon is responsible for this outcome. Explain the phenomenon in brief.