A point mutation occurs in the middle of the coding sequence for agene. Which types of mutations—silent, missense, nonsense, andframeshift—would be most likely to disrupt protein function andwhich would be least likely?
A point mutation occurs in the middle of the coding sequence for agene. Which types of mutations—silent, missense, nonsense, andframeshift—would be most likely to disrupt protein function andwhich would be least likely?
Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
Section: Chapter Questions
Problem 10QP: If the coding region of a gene (the exons) contains 2,100 base pairs of DNA, would a missense...
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Question
A point mutation occurs in the middle of the coding sequence for a
gene. Which types of mutations—silent, missense, nonsense, and
frameshift—would be most likely to disrupt protein function and
which would be least likely?
Expert Solution
Step 1
Mutation is the process of abrupt changes in the nucleotide sequence or gene in the DNA. Mutation leads to defective protein coding gene which affects the phenotype. Agents which induce or cause mutations are called as mutagens.
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