A young adult is taking part in a hepatitis B vaccine phase III clinical trial. Her specific antibody titers are measured several days after each injection as part of the trial. She develops joint aches and swelling, as well as a slight rash, several hours after the third injection. After the study, an examination of her records reveals that she had high antibody titers after the first dose, with increasing titers with each subsequent dose. Which of the following is most likely to be the cause of her negative reaction? a. reaction to the vehicle (a substance in which the viral antigen is suspended). b. Anaphylaxis reaction c. Arthus-type hypersensitivity reaction d. production of antibodies cross-reacting with synovial (joint) antigens and epidermal antigens.

A young adult is taking part in a hepatitis B vaccine phase III clinical trial. Her specific antibody titers are measured several days after each injection as part of the trial. She develops joint aches and swelling, as well as a slight rash, several hours after the third injection. After the study, an examination of her records reveals that she had high antibody titers after the first dose, with increasing titers with each subsequent dose. Which of the following is most likely to be the cause of her negative reaction? a. reaction to the vehicle (a substance in which the viral antigen is suspended). b. Anaphylaxis reaction c. Arthus-type hypersensitivity reaction d. production of antibodies cross-reacting with synovial (joint) antigens and epidermal antigens.

Curren'S Math For Meds: Dosages & Sol

11th Edition

ISBN:9781305143531

Author:CURREN

Publisher:CURREN

Chapter15: Adult And Pediatric Dosages Based On Body Weight

Section: Chapter Questions

Problem 4.4P

See similar textbooks

Similar questions

Two newly developed vaccine candidates (A and B) are tested in mice for their ability to elicit high concentrations of anti-meningococcal antibodies that would provide mucosal as well as bloodstream protection. Also, the ideal candidate vaccine should also provide long-lasting immunity to the infection. The figure below shows the responses to a primary, followed by a secondary immunization to each of the two candidate vaccines. a) Which candidate vaccine elicits the preferred response? What are the three aspects of the preferred response that make it the candidate vaccine of choice? b) What is the likely composition of each vaccine and what evidence from the information above are used to lead to your conclusions? c) To confirm the choice of the preferred candidate vaccine, what type of additional information from the vaccine trials in mice shown above would support this conclusion? Name two additional features of the secondary antibody response to each candidate vaccine that could be…
Briefly give importance of antibody testing in Viral Hepatitis and COVID-19 infection. How will antibody test be useful in controlling the spread of the said infections?
Patient A, who is a recipient of USA-based poly X8650-CA vaccine for its autoimmune allergic rhinitis often visits the doctor twice a month to complain for “idiopathic colds”. Meanwhile Patient B, who is currently taking DOH pilot-used trial 1 mono E2128-PH vaccine for the same condition do not have to visit its doctor. Based on the principles of the antibody production, can you explain why patient A visits more often?
In which of the following cases would treating a patient with an antiserum (purified antibodies) be more helpful than treating them with other drugs? Group of answer choices Purified antibodies would not be helpful in any of these cases If the person has a viral hepatitis infection If the person has eaten a poison produced by bacteria If the person has a fungal skin infection
Considering the current situation of the procurement of COVID-19 vaccine, is it safe to be immunized? Why yes or no?
Assuming that there is a certain new vaccine used in the Philippines. The clinical results were: 200 patients were tested and there were 250 true positives, 50 true negatives, 8 false positives, and 12 false negatives. What is the specificity and sensitivity of the new vaccine? Compute for the predictive value of the vaccine. Is the vaccine recommended for release?
What part of the SARS-CoV-2 virus is a potential target site for a vaccine? Explain your reasoning; include in your discussion the following terms: antigen, epitope, and antibody.
MCQ --Rotarix is a vaccine indicated for the prevention of Rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9). Which of the following is NOT correct regards this vaccine? following immunisation, children may become irritable and experience diarrhoea ill infants or who born with SCID should not be immunized is live-attenuated vaccine derived from the G1P[8] rotavirus strain is prepared for IV administration is given in two doses None of the above
Consider that SARS CoV-2 has a wide range of severity of symptoms, and it can have long incubation periods during which the individual is asymptomatic and may test negative. Comparing SARS CoV-2 with smallpox vs. polio, why is it difficult to contain the virus with quarantine.?
During the current COVID 19 pandemic antibody tests have develop to track whether someone is exposed to COVID 19.If the antibody test results for one person is showing low levels of Igm and Igg in Person ? a)The person in the middle of 2nd exposure of infection b)The person is in the middle of his 3rd exposure or infection c)the person is in middle of his 1st exposure or infection d) the person is in the middle of his 4th exposure or infection
In which of the following cases would treating a patient with an antiserum (purified antibodies) be more helpful than treating them with other drugs? If the person has a fungal skin infection Purified antibodies would not be helpful in any of these cases If the person has eaten a poison produced by bacteria If the person has a viral hepatitis infection
A group of researchers wanted to evaluate the effectiveness of mask-wearing, handwashing, social distancing, and other personal protective measures in preventing COVID-19 infections They recruited two groups of participants. Those in group 1 tested positive for COVID-19, whereas those in group 2 tested negative for COVID-19. Each of the participants in each group had a history of recent contact with someone who was confirmed COVID-19 positive . Thereafter, participants in each group were asked whether they wore a face mask, the type of mask, and the frequency of wearing a mask; whether and how frequently they practiced handwashing; and whether they complied with social distancing guidelines. The above describes which of the following epidemiological study designs ? a. Cohort study b. Descriptive study c. Cross-sectional study d. Case-control study