Aawa pedigree that includes Amanda, Brice, their siblings, and parents. ldentify the genotypes of each person using G and a to represent the dominant and recessive alleles. R What is the probability that Amanda is a carrier of the allele for galactosemia? Same question for Brice? Explain.
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- Unpacking the Problem 70A man’s grandfather has galactosemia, a rare autosomalrecessive disease caused by the inability to process galactose,leading to muscle, nerve, and kidney malfunction. The manmarried a woman whose sister had galactosemia. The womanis now pregnant with their first child.a. Draw the pedigree as described.b. What is the probability that this child will havegalactosemia?c. If the first child does have galactosemia, what is theprobability that a second child will have it?True or false? Reasons that are acceptable by many for C-sections include all except triplets.Olivia S. was born with a rare recessive disorder called tyrosinemia.The next day, Olivia M. was born in a neighboringstate with the same disorder. Tyrosinemia is causedby the lack of an enzyme in the degradation pathway of the aminoacid tyrosine. Accumulation of metabolic intermediates causesprogressive liver dysfunction and kidney problems. One-year-oldOlivia S. is healthy and has no symptoms of the disorder. At thesame age, Olivia M. developed total liver failure. Olivia S. was bornin a state where newborns are tested for tyrosinemia, but Olivia M.was born in a state where newborns are not tested for this disorder.A week after diagnosis, Olivia S. was placed on a low-tyrosinediet and prescribed a drug to block the accumulation of metabolicintermediates. Olivia M. was not diagnosed until she was in liverfailure; she then was placed on a low-tyrosine diet, was prescribedmedication, and underwent a liver transplant. She faces a lifetimeof antirejection drug therapy and may require a…
- Ch. 14-6 A mutation on an autosome causes a particular protein to be overproduced, and the excess protein accumulates in the liver and damages it. Would the resulting disorder most likely be inherited in an autosomal dominant or recessive pattern?9) Polysaccharide Storage Myopathy (PSM) is a dominant autosomal hereditary condition in horses that can cause muscle damage and inability to move. It is often referred to as “tying-up”. Equine hyperkalemic periodic paralysis (HYPP) is also a dominant autosomal hereditary condition in horses that has been traced back to a horse named Impressive who died in 1995 at the age of 26. Symptoms of HYPP include muscle twitching and unpredictable paralysis attacks that can lead to sudden death. Recall that with dominant disorders, only one dominant allele will result in the condition being manifested. a. A stallion with HYPP and PSSM whose mother had neither disorder is crossed with a mare who has neither HYPP or PSSM. Construct a punnett square and state the probability that this cross will result in a foal with neither HYPP or PSSM (think of this as a two-gene cross). b. What are the possible genotypes and phenotypes of all the foals? c. Probability of a foal without HYPP or PSSM?Phenylketonuria (PKU) is an inheritable disorder whereby phenylalanine accumulates in the blood. If left untreated, the disorder can lead to severe health problems and intellectual disabilities.If individuals II-2 and II-8 had a child, what is the percentage chance that this child will suffer from PKU?
- 10) Phenylketonuria (PKU) is a recessive disorder. Jack and Jane look normal but have a child with PKU. Therefore, what are the genotypes of Jack and Jane? __________________________________Phenylketonuria (PKU) is a human hereditary disease resulting from the inability of the body to process the chemical phenylalanine, which is contained in the protein we eat. PKU is manifest in early infancy and, if it remains untreated, generally leads to cognitive impairment. PKU is caused by a recessive allele with simple Mendelian inheritance. A couple intends to have children but consults a genetic counselor because the man has a sister with PKU and the woman has a brother with PKU. There are no other known cases in their families. They ask the genetic counselor to determine the probability that their first child will have PKU. What is this probability?2) Indicate the pattern of inheritance for the human genetic disorders. Use letter symbols for your answers (AR, AD, XR,XD, M) where appropriate. Table 2. HUMAN GENETIC DISORDER PATTERN OF INHERITANCE Marfan Syndrome Sickle Cell Anemia Classical Hemophilia Hypophosphatemia Cystic Fibrosis Phenylketonuria Huntington’s Disease Tay Sachs Disease Neurofibromatosis Alkaptonuria Xeroderma pigmentosum Kearns-Sayre Syndrome Achondroplasia Beta thalassemia Duchene Muscular Dystrophy
- 14. Type 1 fucosidosis is a rare human disease. Patients cannot hydrolyze the disaccharide fucose, and as a result have severe neurological decline and die by age 6. The disease is due to a defect in the gene that encodes the lysosomal enzyme that breaks down fucose (α-1-fucosidase), and is inherited in an autosomal recessive manner. Jane and John have a child who has Type 1 fucosidosis. What is the probability that their next child will also have the disease? A. 4/4 or 100% B. No chance C. 3/4 D. 1/4>chromosomal…Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a disorder that affects the normal functionof red blood cells and can eventually lead to anemia. The trait is controlled by a recessive allele found onthe X chromosome. An affected son was born to a man and woman who were unaffected. The woman’smother was affected while the father was normal.a. Indicate the gene notation.b. Give the genotypes of the affected boy’s parents.c. Derive the genotypic and phenotypic ratios for the offspring. Show and label your solutions properly.d. What is the probability that they will have a phenotypically normal daughter as their first child?