Adipose tissue cannot resynthesize triacylglycerols from glycerol released during lipolysis (fat breakdown). Why not? Describe the metabolic route that is used to generate a glycerol compound for tri- acylglycerol synthesis.
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Q: Triacylglycerols in adipose tissue do not enter the bloodstream as triacyglycerolsexplain
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- Triacylglycerols in adipose tissue do not enter the bloodstream as triacyglycerolsexplainFrom what fatty acid are most of the eicosanoids derived?List several medical conditions in which the suppression ofeicosanoid synthesis may appear to be advantageous.Glucokinase acts as a glucose sensor in hepatocytes (livercells), a- and b-cells in the pancreas, enterocytes (intestinalwall cells), and the hypothalamus (a control center in thebrain of numerous physiological processes). Explain whyglucokinase can perform this role.
- Describe the roles of dihydroxyacetone phosphate and fatty acids in the synthesis of triacylglycerolOne metabolic scenario that leads to insulin resistance is the elevation of the conccentration of free fatty acids in skeletal muscle cells. Would you expect increased activity of diacylglycerol acyltransferas (DGAT) to reduce or exacerbate the resistance? Explain.The removal of fatty acids from triacylglycerols leaves glycerol. Show how the actions of glycerol kinase and glycerol-3-phosphatedehydrogenase on glycerol produce an intermediate of glycolysis.
- Compare and contrast the following items related to lipid metabolism. Cite their main similarities/or differences. 1.lysophosphatidylcholine vs. phosphatidylethanolamine 2.trimyristin vs. triolein. 3. ACP vs. carnitine-acyl transferase.In fatty acid biosynthesis explain the following two parts -(a) What effect will an increase in oxaloacetate in mitochondria have on fatty acid biosynthesis?(b) How insulin and glucagon affect fatty acid oxidation and biosynthesis reactions/pathways, name them.Fatty acids are stored in adipose tissue, as triacylglycerol (TAG) forms. TAGs are degraded as glycerol and fatty acids where energy is required. Based on that knowledge explain: How these products are used in the adipose, liver, and other tissue? Why glycerol can not be metabolized in adipose tissue?
- Briefly explain why chicken fat, which largely consists of various triacylglycerols, has such a higher energy content per mole compared to sucrose.Only the carbon skeleton of amino acids is used in gluconeogenesis but not fatty acids. How can fatty acid oxidation in the liver then provide fuel for the brain? Explain the pathways and compounds involvedSkeletal muscle cannot synthesize fatty acids, yet it producesthe enzyme acetyl-CoA carboxylase. Explain the role of thisenzyme