(a)Draw Histidine in all its protonated form and include the pKa's where appropriate. (b) Calculate the fraction of histidine that has its imidazole side chain protonated at pH7.3. The pKa values for histidine are pK1 = 1.8, pKr (imidazole) = 6.0, and pK2 = 9.2 %3D

(a)Draw Histidine in all its protonated form and include the pKa's where appropriate. (b) Calculate the fraction of histidine that has its imidazole side chain protonated at pH7.3. The pKa values for histidine are pK1 = 1.8, pKr (imidazole) = 6.0, and pK2 = 9.2 %3D

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter24: Amines And Heterocycles

Section24.9: Heterocyclic Amines

Problem 21P

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Question

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(a)Draw Histidine in all its protonated form
and include the pKa's where appropriate.
(b) Calculate the fraction of histidine that has
its imidazole side chain protonated at pH7.3.
The pKa values for histidine are pK1 = 1.8, pKr
(imidazole) = 6.0, and pK2 = 9.2

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