The monoanion of adenosine monophosphate (AMP) is an intermediate in phosphate metabolism: А—О—р—он АMP—ОН- where A = adenosine. If the pKa for this anion is 7.21, what is the ratio of [AMP-OH ] to [AMP-02 ]in blood at pH 7.4?

The monoanion of adenosine monophosphate (AMP) is an intermediate in phosphate metabolism: А—О—р—он АMP—ОН- where A = adenosine. If the pKa for this anion is 7.21, what is the ratio of [AMP-OH ] to [AMP-02 ]in blood at pH 7.4?

Introduction to General, Organic and Biochemistry

11th Edition

ISBN:9781285869759

Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres

Chapter22: Proteins

Section: Chapter Questions

Problem 22.94P

See similar textbooks

Related questions

Q: If H218O is used in the hydrolysis reaction catalyzed by lysozyme, which ring will contain the…

A: Lysozyme here is a glycoside hydrolase. This can damage the bacterial cell walls by catalyzing the…

Q: Glutamic acid has three ionizable groups. The pKa of a-COOH is 2.19; a-NH 3+, 9.67; and the R-group,…

A: Given - Pka of α-COOH of glutamic acid = 2.19 PKa of α-NH3+ of glutamic acid = 9.67…

Q: If H218O is used in the hydrolysis reaction catalyzed by lysozyme, which ring will contain the…

A: Lysozymes here is a glycoside hydrolase. This can harm the bacterial cell dividers by catalyzing the…

Q: Calculate the isoelectric point of aspartic acid

A: Aspartic acid is amino acid. Amino acids are the building blocks of life. Protein is made up of…

Q: At what pH will the amino group of cysteine be 50% deprotonated? The pKa values are 2.2, 8 and 9.6?…

Q: Which molecule is the enantiomer of L-alanine, shown below? COOH L-alanine NH2 CH, ÇOOH NH COOH COOH…

A: Amino acids are generally denoted by L and D confirmation, similar to carbohydrates. When the NH2…

Q: what are the lewis structures of these: H3PO4 SO42- Palmitic acid (in pH 7.4) Glycerol Water…

A: Lewis structure are drawn by making dots on the symbol of atom the number of dots are equal to their…

Q: Explain the difference in the pKa values of the carboxyl groups of alanine, serine, and cysteine.

A: The compounds in which both amino (NH2) and carboxylic acid (COOH) group are present are known as…

Q: The tetrapeptide structure shown below contains one amino acid that occurs twice. Which is it and in…

Q: Lysine has the following pK a values: pK 1 = 2.18 pK 2 = 8.95 pK R = 10.79 Give the structure and…

A: Lysine is an amino acid and it has two functional group which are amine and carboxyl group and they…

Q: - What is the dominant form of aspartic acid (a triprotic acid (H3A+)) at a pH of 50 (pKa1 = 1.990,…

A: In Q4 the correct option is 5-choices 1,3 and 4 are correct this is so because the stronger the acid…

Q: Tyrosine, Tyr, Y coot 1 8P + PO - соо H₂N-C-HH3N"-"C-H = H₂N-C-H CH₂ 1 CH₂ PH-Pha= 2.20 OH (+1) CONS…

A: The isoelectric point of an amino acid is the pH at which the amino acid has a neural charge...

Q: What is the pKa of sodium hydrogen oxalate (C2H3NaO5)?

A: The chemical formula of sodium hydrogen oxalate is (C2H3NaO5) The structure of the compound is :

Q: The oxygen in water is primarily (99.8%) 1°0, but water enriched with the heavy isotope 180 is also…

A: When Aldehydes and ketones undergo addition of water, the carbonyl carbon forms gem-diols. The…

Q: Given the structures of cysteine, serine and glycine: H,N– CH- -OH H,N-CH- OH H,N- CH- -OH ČH2 CH2…

Q: Calculate the pH of a 0.0101 M solution of arginine hydrochloride (arginine · HCI, H, Arg*).…

A: Concentration of solution = 0.0101M

Q: (a) Glycine is present predominantly as the species "HaN-CH2-COOH. (b) The average net charge of…

A: Solution- (a) At I glycine present predominantly as the NH3+-CH-COOH. (b) At II pH = pKA, of…

Q: A chemist wanted to test his hypothesis that the disulfide bridges that form in many proteins do so…

A: The native enzyme has four disulfide linkages. So the denatured enzyme should have eight cysteine…

Q: MCQ 22: Consider the reaction: (NH),CO + H,0 - NH, + CO. The substrate in this reaction is A. urease…

Q: If an acid with a pKa of 5.3 is in an aqueous solution of pH 5.7, what percentage of the acid is…

A: Henderson Hasselbalch equation is given below. During a dissociation of acid in aqueous solution,…

Q: What is the structure, origin and catalytic role of Biotin?

A: Answer: Structure of Biotin: Biotin also…

Q: In humans, the final product of purine degradation from DNA is uric acid, pKa = 5.61, which is…

A: There are two types of bases/acids. One is strong base/acid which is completely dissociable in into…

Q: For aspartic acid, the pka's of the a-COOH and a-NH3* are 2.1 and 9.8, respectively, whereas the pKa…

A: When pH is greater than pKa then depronated form. When pH is less than pKa then protonated form.…

Q: The imidazole ring on Histamine has a pKa of 6.5. What is the %ionization of this group at pH 8.2?

Q: What is the net charge of the predominate form of free Threonine at pH 8.0?

A: We have to calculate the net charge on threonine at pH of 8.

Q: A solution of RNA with a concentration of 40 ugmL-1 has an absorbance at A260 of 1.0. What is the…

A: Given: When absorbance is 1, concentration is 40 ug/ml. 1. When absorbance is 0.65, concentration…

Q: 28.) The purine with the fewest oxygen atoms always base pairs with B) guanine in RNA. A) adenosine…

A: 28)answer will be option (E) uracil The four nucleo bases in DNA are guanine, adenine, cytosine and…

Q: Arginine is an amino acid which has the following pKa values: pK1: 2.17, pK2: = 9.04, pKR = 12.48.…

A: So, the net charge of arginine at pH = 4 will be +1.

Q: 7. The structure of the amino acid alanine is C- COOH H Give the structural formula of the species…

A: The chemical species that contain an amino group and a carboxylic acid group on the same carbon atom…

Q: 2 W S X A biological molecule is shown here. What is the most likely classification of this…

Q: Consider the cysteine molecule. Choose the structural formula for the anion formed in base. O HS C…

A: Amino acids are those in which carbon is attached with COOH group, amino group and R group. Amino…

Q: Is C60 aromatic?

A: Allotrope means an element can exist in more than one form like, carbon atom exists in three…

Q: How does aqueous Silver nitrate, AGNO3, works against neonatal conjunctivitis (inflammation of the…

Q: Draw the diazonium cation formed when cytosine reacts with NaNO2 in the presence of HCI. NH2 NANO,…

A: First, the mixture of NaNO2 and HCl produces NO+ cation. The NH2 group present in the given molecule…

Q: 22 is -o ben ealua9 l b ade A compound. lomy

A: Given : 40% carbon, 6.71% Hydrogen and 53.29% Oxygen. To find : Empirical formula and molecular…

Q: Benzoic acid has a pKa = 4.20 at a pH of 6.20 the ratio [A-]/[HA] is what? O 1:100 1:50 1:10 1:1

Q: 32. Write the condensed structural formula for the C3H7C1 molecules you drew. (1) (2) elob 33. How…

A: Isomers are those compounds which have same molecular formula but different structural formula.

Q: The pKa values for the amino and carboxyl groups of alanine are 9.69 and 2.35, respectively.…

A: In any buffer, if any strong acid gets added then the existing conjugate salt basically abstracts…

Q: Glutamic acid has three ionizable groups. The pKa of α-COOH is 2.19; α-NH 3 + , 9.67; and the…

A: Glutamic acid is a acidic amino acid having 2 COOH groups and one NH2 group. Three pKa values are…

Q: What is the net charge of glycine at ph 2.0 What is the net charge of tyrosine at ph 9.5 What is…

Q: A carbon is covalently attached to =O, -CH2-CH3, and -CH3. It is best called a(n): aldehyde…

A: Since you have posted multiple questions, we are entitled to answer the first only.

Q: The amino acid "arginine (Arg)" has the following form: Arg, HArg, H₂ Arg, H3 Arg²+, Which is the…

A: Arginine is an amino acid and it has three ionizable protons, that is why it has three pKa values.…

Q: Consider the following five weak acids: Succinic acid: pKa = 4.16HOBr: Ka = 2.06 x…

A: Given weak acids Succinic acid: pKa = 4.16HOBr: Ka = 2.06 x 10-9Dinicotinic: pKa =…

Q: BrCN

A: The given peptide is, The given reagent is BrCN.

Q: The amino acid histidine has ionizable groups with pKą values of 1.8, 6.0, and 9.2, as shown. COO…

A: In the given question we have, The pKa values are given which are= 1.8, 6.0 and 9.2 The…

Q: At what pH does a 0.02 M solution of Ala-Cys exhibit a net charge of -1.5? The pK, for the a-…

Q: The isoelectric point (pl) of phenylalanine is pH 5.5. Draw the structure of the major form of…

Q: Brucine is a poisonous alkaloid obtained from Strychnos nux vomica, a tree that grows in India, Sri…

A: The free amino group of amino acid phenylalanine form amide bond on reaction with acetic anhydride.…

Q: (B.) 45 Whhat is the expected structure of alanine, 11N G COOH CH in a neutral nedium HN--COOH H,N…

A: in Q.No 45 the expected structure of alanine in neutral solution. we know that the neutral…

Q: Which of the following amino acids is most likely to have a positively-charged side group under…

A: The physiological pH is 7.4

Question

The monoanion of adenosine monophosphate (AMP) is an
intermediate in phosphate metabolism:
А—О—р—он
АMP—ОН-
where A = adenosine. If the pKa for this anion is 7.21,
what is the ratio of [AMP-OH ] to [AMP-02 ]in blood
at pH 7.4?

Expert Solution

This question has been solved!

Explore an expertly crafted, step-by-step solution for a thorough understanding of key concepts.

This is a popular solution!

SEE SOLUTION Check out a sample Q&A here

Step 1

VIEW

Step 2

VIEW

Trending now

This is a popular solution!

Step by step

Solved in 2 steps

SEE SOLUTION Check out a sample Q&A here

Similar questions

22-49 Based on your knowledge of the chemical properties of amino acid side chains, suggest a substitution for leucine in the primary structure of a protein that would probably not change the character of the protein very much.
A chemist, during the course of an analysis, runs across a chemical composed of carbon, hydrogen, and oxygen in the proportion 1:2:1 and having a six-sided molecular shape. It is probably (a) a pentose, (b) an amino acid, (c) a fatty acid, (d) a monosaccharide, (e) a nucleic acid.
The amino acid alanine is a solid at room temperature and has a melting point of 315 °C, while pyruvic acid (CH 3COCO 2H) has a similar molecular weight but is a liquid at room temperature with a boiling point of 165 °C. Account for the difference.
What is the molecular weight of ibuprofen, C13H18O2?
22-62 Distinguish between intermolecular and intramolecular hydrogen bonding between backbone groups. Where in protein structures do you find one, and where do you find the other?
22-61 Polyglutamic acid (a polypeptide chain made only of glutamic acid residues) has an a-helix conformation below pH 6.0 and a random-coil conformation above pH 6.0. What is the reason for this conformational change?
22-85 Denaturation is usually associated with transitions from helical structures to random coils. If an imaginary process were to transform the keratin in your hair from an (-helix to a (-pleated sheet structure, would you call the process denaturation? Explain.
22-59 What is the effect of salt bridges on the tertiary structure of proteins?
22-97 Gelatin is derived from collagen by denaturation. Is a gelatin dessert likely to be a good source of dietary protein?
1 Hyaluronic acid acts as a lubricant in the synovial fluid of joints. In rheumatoid arthritis, inflammation breaks hyaluronic acid down to smaller molecules. Under these conditions, what happens to the lubricating power of the synovial fluid?
22-53 Do iron and zinc ions play role in protein structure? If so, what is the role for either or both?