Amides are comparably unreactive to nucleophilic acyl substitution, yet the B-lactam antibiotics wn) are reactive with a hydroxyl group side chain of an amino acid. Why? R HO

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter17: Carboxylic Acids
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1. Amides are comparably unreactive to nucleophilic acyl substitution, yet the B-lactam antibiotics
shown) are reactive with a hydroxyl group side chain of an amino acid. Why?
R
HO
Transcribed Image Text:1. Amides are comparably unreactive to nucleophilic acyl substitution, yet the B-lactam antibiotics shown) are reactive with a hydroxyl group side chain of an amino acid. Why? R HO
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