Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol (Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system. но Haloperidol Br. (A) 1-Bromo-4-chlorobenzene COOCH3 COOCH, COOCH (В) (C) COOCH, + NH2 Methyl acrylate THN Fluoro- Succinic (F) benzene anhydride (E)

Organic Chemistry
8th Edition
ISBN:9781305580350
Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Chapter22: Reactions Of Benzene And Its Derivatives
Section: Chapter Questions
Problem 22.61P
icon
Related questions
Question

Given this retrosynthetic analysis, propose a synthesis for haloperidol.

Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol
(Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system.
но
Haloperidol
Br.
(A)
1-Bromo-4-chlorobenzene
COOCH3
COOCH,
COOCH
(В)
(C)
Transcribed Image Text:Among the first antipsychotic drugs for the treatment of schizophrenia was haloperidol (Haldol), a competitive inhibitor of dopamine receptor sites in the central nervous system. но Haloperidol Br. (A) 1-Bromo-4-chlorobenzene COOCH3 COOCH, COOCH (В) (C)
COOCH, +
NH2
Methyl acrylate
THN
Fluoro-
Succinic
(F)
benzene
anhydride
(E)
Transcribed Image Text:COOCH, + NH2 Methyl acrylate THN Fluoro- Succinic (F) benzene anhydride (E)
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps with 3 images

Blurred answer
Knowledge Booster
Ammonium Salts
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, chemistry and related others by exploring similar questions and additional content below.
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9781305580350
Author:
William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote
Publisher:
Cengage Learning
Organic Chemistry
Organic Chemistry
Chemistry
ISBN:
9781305080485
Author:
John E. McMurry
Publisher:
Cengage Learning
General, Organic, and Biological Chemistry
General, Organic, and Biological Chemistry
Chemistry
ISBN:
9781285853918
Author:
H. Stephen Stoker
Publisher:
Cengage Learning
Organic And Biological Chemistry
Organic And Biological Chemistry
Chemistry
ISBN:
9781305081079
Author:
STOKER, H. Stephen (howard Stephen)
Publisher:
Cengage Learning,