An immobilized enzyme plug flow reactor (PFR) contains a very porous honeycomb structure that has an enzyme immobilized on its surface. The substrate (S) enters the reactor at a concentration of 0.05 mole L-1along with an uncompetitive inhibitor (I) with a concentration of 0.01 mole L-1. The enzyme properties are such that: Vmax= 1.2 x 10-8mole cm-2sec-1, Km= 0.12 mole L-1. For the inhibitor KI= 0.05 mole L-1. The flowrate through the reactor is such that kL= 10-4cm sec-1. The surface area to volume ratio

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An immobilized enzyme plug flow reactor (PFR) contains a very porous honeycomb structure that has an enzyme immobilized on its surface. The substrate (S) enters the reactor at a concentration of 0.05 mole L-1along with an uncompetitive inhibitor (I) with a concentration of 0.01 mole L-1. The enzyme properties are such that: Vmax= 1.2 x 10-8mole cm-2sec-1, Km= 0.12 mole L-1. For the inhibitor KI= 0.05 mole L-1. The flowrate through the reactor is such that kL= 10-4cm sec-1. The surface area to volume ratio of the honeycomb structure in the bioreactor is 1 cm-1. Estimate the residence time needed to achieve a 90 % conversion of the substrate. If the flowrate through the reactor is 100 L hr-1, what is the total volume (L) of the reactor needed to achieve this conversion? If the L/D ratio of the reactor is 10, what are the dimensions (ft) of the reactor? Repeat these calculations if external mass transfer effects are ignored.

 

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