Can you please help verify the following Ochem reactionWe are using o-toluidine and acetic anhydride to produce an acetamideWhich of the 2 reactions is correct? (see image) I think its the second one that will produce N-(2-methylphenyl) acetamide, but I'm not sure NH₂o-toluidineCH,CH.NHzNH₂o-toluidineCH:CH.NHzCH3CH3H₂CH₂CAcetic anhydride(CH3CO) ₂0Acetic anhydride(CH3CO) ₂0CH3CH3HNN-phenylacetamideC8H⁹NOCH3C₂H11NONHCH3CH3N-(2-methylphenyl) acetamideH₂CAcetic acidCH3COOHH₂COHAcetic acidCH3COOH

For acylation acetic anhydride is the best reagent. If acylation is takes place at Nitrogen then it…

an you please help verify the following Ochem reaction We are using o-toluidine and acetic anhydride to produce an acetamide Which of the 2 reactions is correct? (see image) I think its the second one that will produce N-(2-methylphenyl) acetamide, but I'm not sure

an you please help verify the following Ochem reaction We are using o-toluidine and acetic anhydride to produce an acetamide Which of the 2 reactions is correct? (see image) I think its the second one that will produce N-(2-methylphenyl) acetamide, but I'm not sure

Organic Chemistry

9th Edition

ISBN:9781305080485

Author:John E. McMurry

Publisher:John E. McMurry

Chapter22: Carbonyl Alpha-substitution Reactions

Section22.SE: Something Extra

Problem 59AP

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Question

Can you please help verify the following Ochem reaction

We are using o-toluidine and acetic anhydride to produce an acetamide

Which of the 2 reactions is correct? (see image)

I think its the second one that will produce N-(2-methylphenyl) acetamide, but I'm not sure

NH₂
o-toluidine
CH,CH.NHz
NH₂
o-toluidine
CH:CH.NHz
CH3
CH3
H₂C
H₂C
Acetic anhydride
(CH3CO) ₂0
Acetic anhydride
(CH3CO) ₂0
CH3
CH3
HN
N-phenylacetamide
C8H⁹NO
CH3
C₂H11NO
NH
CH3
CH3
N-(2-methylphenyl) acetamide
H₂C
Acetic acid
CH3COOH
H₂C
OH
Acetic acid
CH3COOH

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