Antibiotics prevent virtually every step in the Central Dogma of bacteria. Rifampicin, for example, inhibits transcription while streptomycin inhibits translation.

Human Heredity: Principles and Issues (MindTap Course List)
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Chapter8: The Structure, Replication, And Chromosomal Organization Of Dna
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Many microbes (as well as other organisms) produce antibiotics. A natural compound produced by one organism that inhibits or kills another unrelated organism is commonly defined as an antibiotic. Thousands of antibiotics have been identified and characterized. Antibiotics prevent virtually every step in the Central Dogma of bacteria. Rifampicin, for example, inhibits transcription while streptomycin inhibits translation. However, no antibiotic has ever been discovered that directly affects DNA replication by inhibiting the action of DNA polymerases. "Why not?" 

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