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Assume that the following mRNA segment has been translated.   5’-UACCGAAUGUCU-3’   Note for letters a and b: Use the three-letter abbreviation of amino acid; separate amino acids with a hyphen: do not include the stop codon.   Example:  ala-cys-glu   a. Using the table of the genetic code, determine the sequence of amino acids.    b. If mutation occurs by substitution of the 12th nucleotide with cytidine-5’-monophosphate, what is the resulting amino acid sequence?  c. What type of mutation occurred? Choose from same sense, missense and non-sense.

Assume that the following mRNA segment has been translated.   5’-UACCGAAUGUCU-3’   Note for letters a and b: Use the three-letter abbreviation of amino acid; separate amino acids with a hyphen: do not include the stop codon.   Example:  ala-cys-glu   a. Using the table of the genetic code, determine the sequence of amino acids.    b. If mutation occurs by substitution of the 12th nucleotide with cytidine-5’-monophosphate, what is the resulting amino acid sequence?  c. What type of mutation occurred? Choose from same sense, missense and non-sense.

Essentials Health Info Management Principles/Practices
Essentials Health Info Management Principles/Practices
4th Edition
ISBN:9780357191651
Author:Bowie
Publisher:Bowie
Chapter10: Introduction To Coding And Reimbursement
Section10.1: Clinical Classification Systems
Problem 5E
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Consider the mRNA sequence below. Assume that the following mRNA segment has been translated.

 

5’-UACCGAAUGUCU-3’

 

Note for letters a and b: Use the three-letter abbreviation of amino acid; separate amino acids with a hyphen: do not include the stop codon.

 

Example:  ala-cys-glu

 

a. Using the table of the genetic code, determine the sequence of amino acids.   

b. If mutation occurs by substitution of the 12th nucleotide with cytidine-5’-monophosphate, what is the resulting amino acid sequence? 

c. What type of mutation occurred? Choose from same sense, missense and non-sense.

first base U C A G U UUU UUC }phe UUA 1 UUG leu CUU CUC leu CUA CUG AUU AUC ile AUA AUG met (start) GUU GUC val GUA GUG UCU UCC UCA UCG CCU CCC CCA CCG ACU ACC ACA ACG GCU GCC GCA GCG second base ser pro thr ala A UAU} tyr UAA Stop UAG Stop CAU 1 his CAC CAA 1 CAG gin AAU asn AAC AAA AAG lys GAU asp GAC GAA GAG glu G UGC} cys UGA Stop UGG trp CGU CGC CGA arg CGG AGU ser AGC AGA AGG arg GGU GGC gly GGA GGG MCAGUOAGUUAGUUAG third base
Transcribed Image Text:first base U C A G U UUU UUC }phe UUA 1 UUG leu CUU CUC leu CUA CUG AUU AUC ile AUA AUG met (start) GUU GUC val GUA GUG UCU UCC UCA UCG CCU CCC CCA CCG ACU ACC ACA ACG GCU GCC GCA GCG second base ser pro thr ala A UAU} tyr UAA Stop UAG Stop CAU 1 his CAC CAA 1 CAG gin AAU asn AAC AAA AAG lys GAU asp GAC GAA GAG glu G UGC} cys UGA Stop UGG trp CGU CGC CGA arg CGG AGU ser AGC AGA AGG arg GGU GGC gly GGA GGG MCAGUOAGUUAGUUAG third base
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