b. (Requires more than 1 step!) Hints: requires more than 1 step; you may use any other reagents necessary like bases, metals, etc.; you may use work-ups as we have in the past; you may use solvents as we have in the past; you will need to use chemistry that we have studied in past units this year; remember whether nitrogen or oxygen is a better nucleophile. Lastly you will need to use the following reaction that we have not yet discussed this year! HBr with organic peroxides Br Product! `OH Salmeterol (B2 adrenoceptor agonist) QH -NH2 `OH Br но B (3 starting materials)

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter20: Acidity And Pka Of Phenols
Section: Chapter Questions
Problem 11E
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give  synthesis 

b. (Requires more than 1 step!)
Hints: requires more than 1 step; you may use any other reagents necessary like bases,
metals, etc.; you may use work-ups as we have in the past; you may use solvents as we
have in the past; you will need to use chemistry that we have studied in past units this year;
remember whether nitrogen or oxygen is a better nucleophile. Lastly you will need to use
the following reaction that we have not yet discussed this year!
HBr with organic peroxides
Br
он
Product!
он
`OH
Salmeterol
(B2 adrenoceptor agonist)
он
-NH2
OH
Br
но
A
в он
(3 starting materials)
Transcribed Image Text:b. (Requires more than 1 step!) Hints: requires more than 1 step; you may use any other reagents necessary like bases, metals, etc.; you may use work-ups as we have in the past; you may use solvents as we have in the past; you will need to use chemistry that we have studied in past units this year; remember whether nitrogen or oxygen is a better nucleophile. Lastly you will need to use the following reaction that we have not yet discussed this year! HBr with organic peroxides Br он Product! он `OH Salmeterol (B2 adrenoceptor agonist) он -NH2 OH Br но A в он (3 starting materials)
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