Based on Pruisner (2013), match each of the following terms with its appropriate definition or description.                                                                         PRNP gene                                                                        CPEB (cytoplasmic polyadenylation element binding) protein                                                                        NFT (neurofibrillary tangle)                                                                        A673T-mutated AAP                                                                        MAPT gene A. a "nonpathogenic prion" B. encodes PrPC (the normal cellular form of prion protein) C. encodes tau protein;  mutations in this gene underlie many familial FTDs (frontotemporal dementias) D. tau-rich fibril associated with many neurodegenerative diseases E. a missense mutation in β-secretase which appears to protect against late-onset Alzheimer's disease

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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  1. Based on Pruisner (2013), match each of the following terms with its appropriate definition or description. 

                                                                          

    PRNP gene

                                                                          

    CPEB (cytoplasmic polyadenylation element binding) protein

                                                                          

    NFT (neurofibrillary tangle)

                                                                          

    A673T-mutated AAP

                                                                          

    MAPT gene

    A.

    a "nonpathogenic prion"

    B.

    encodes PrPC (the normal cellular form of prion protein)

    C.

    encodes tau protein;  mutations in this gene underlie many familial FTDs (frontotemporal dementias)

    D.

    tau-rich fibril associated with many neurodegenerative diseases

    E.

    a missense mutation in β-secretase which appears to protect against late-onset Alzheimer's disease

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