Based on your answer to parts A - C, draw the correct regio- and stereoisomer of the product in the space provided. Provide a systematic name of the substrate. Provide a systematic name of the product (see section 8.3 for alkene nomenclature). Draw a transition state structure of the reaction with partial bonds and partial charges indicated. Draw an energy diagram for the E2 reaction on the previous page. Your reaction coordinate diagram should: Include structures of starting materials, products, and transition states at correct relative energies. Indicate the activation energy of the rate determining step and whether the reaction is endothermic or exothermic.
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
- Based on your answer to parts A - C, draw the correct regio- and stereoisomer of the product in the space provided.
- Provide a systematic name of the substrate.
- Provide a systematic name of the product (see section 8.3 for
alkene nomenclature).
- Draw a transition state structure of the reaction with partial bonds and partial charges indicated.
- Draw an energy diagram for the E2 reaction on the previous page. Your reaction coordinate diagram should:
- Include structures of starting materials, products, and transition states at correct relative energies.
- Indicate the activation energy of the rate determining step and whether the reaction is endothermic or exothermic.
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