Before a sugar can be analyzed by gas chromatography(GLC) or GLC/MS, it must be converted to a volatile derivative. Why can’t sugars be analyzed directly?

Basic Clinical Laboratory Techniques 6E
6th Edition
ISBN:9781133893943
Author:ESTRIDGE
Publisher:ESTRIDGE
Chapter6: Basic Clinical Chemistry
Section6.5: Blood Glucose And Hemoglobin A1c
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Before a sugar can be analyzed by gas chromatography
(GLC) or GLC/MS, it must be converted to a volatile derivative. Why can’t sugars be analyzed directly?

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